887344-27-6

Basic information

• Product Name: 3-(4-Methoxy-phenyl)-thiomorpholine
• CAS NO: 887344-27-6
• Molecular Formula: C₁₁H₁₅NOS
• Molecular Weight: 209.31
• Mol File: 887344-27-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Methoxy-phenyl)-thiomorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methoxy-phenyl)-thiomorpholine(887344-27-6)
• EPA Substance Registry System: 3-(4-Methoxy-phenyl)-thiomorpholine(887344-27-6)

Safety Data

• Hazardous Substances Data: 887344-27-6(Hazardous Substances Data)

Usage

General Description

3-(4-Methoxy-phenyl)-thiomorpholine is a chemical compound with the chemical formula C10H15NOS. It is a thiomorpholine derivative that contains a thiomorpholine ring with a 4-methoxyphenyl group attached to one of its carbon atoms. 3-(4-Methoxy-phenyl)-thiomorpholine is used in organic synthesis and pharmaceutical research due to its potential biological activities. It has been studied for its potential antiparasitic, antifungal, and antitumor properties. Its unique chemical structure and potential biological activities make it an interesting target for further research and development in the field of medicinal chemistry.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridines

A large proportion of medicinally relevant molecules bear nitrogen and sp3-hybridized carbon functionalities. Overwhelmingly, these atoms are found as part of (hetero)cyclic structures. Despite their importance, synthetic approaches to saturated nitrogen heterocycles are limited to several established stoichiometric alkylation techniques, as well as a few methods involving C-H bond activation. The synthetic community remains interested in more general, mild, and sustainable ways to access these motifs. Here we describe a dual-catalyst system composed of an iridium photocatalyst and a lithium phosphate base that is capable of selectively homolyzing the N-H bond of 4-alkyl-1,4-dihydropyridines, presumably by proton-coupled-electron-transfer (PCET), and mediating efficient cyclization of the resultant carbon-centered radicals with tethered imines. The outcome of this transformation is access to a broad range of structurally complex nitrogen heterocycles obtainable from simple aldehyde starting materials in a highly chemoselective manner.

SnAP reagents for the transformation of aldehydes into substituted thiomorpholines - An alternative to cross-coupling with saturated heterocycles

It's a SnAP! The transformation of aldehydes into N-unsubstituted 3-thiomorpholines provides a convenient alternative to metal-catalyzed cross-coupling reactions, which are generally unsuited to the functionalization of saturated N-heterocycles. A copper-mediated radical cyclization is the key to the mild conditions, high functional group tolerance, and broad substrate scope offered by these reagents. Copyright