88759-59-5Relevant articles and documents
Method for preparing levorotatory oxiracetam crystal form II through pH method
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Paragraph 0062; 0063; 0064; 0065; 0081, (2017/09/01)
The invention relates to a preparation method of a levorotatory oxiracetam crystal form II. The method comprises the steps of adopting S-4-chlorine-3-hydroxybutyrate and sodium azide as starting raw materials for preparing to obtain high-purity (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide; using acetic acid/ammonium hydroxide for preparing to obtain the (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide crystal from II through a pH method. The optical purity is 99.9 percent or above, and the product quality of the (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide crystal from II is greatly improved.
Biocatalytic cascade for the synthesis of enantiopure β-azidoalcohols and β-hydroxynitriles
Schrittwieser, Joerg H.,Lavandera, Ivan,Seisser, Birgit,Mautner, Barbara,Kroutil, Wolfgang
experimental part, p. 2293 - 2298 (2009/08/17)
A three-step, two-enzyme, one-pot reaction sequence starting from prochiral a-chloroketones leading to enantiopure (3- azidoalcohols and (3-hydroxynitriles is described. Asymmetric bioreduction of a-chloroketones by hydrogen transfer catalysed by an alcohol dehydrogenase (ADH) established the stereogenic centre in the first step to furnish enantiopure chlorohydrin intermediates. Subsequent biocatalysed ring closure to the epoxide and nucleophilic ring opening with azide, N3-, or cyanide, CN-, both catalysed by a nonselective halohydrin dehalogenase (Hhe) proceeded with full retention of configuration to give enantiopure (-azidoalcohols and (3-hydroxynitriles, respectively. Both enantiomers of various optically pure (-azidoalcohols and (-hydroxynitriles were synthesised.