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Method for preparing levorotatory oxiracetam crystal form II through pH method
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, (2017/09/01)
The invention relates to a preparation method of a levorotatory oxiracetam crystal form II. The method comprises the steps of adopting S-4-chlorine-3-hydroxybutyrate and sodium azide as starting raw materials for preparing to obtain high-purity (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide; using acetic acid/ammonium hydroxide for preparing to obtain the (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide crystal from II through a pH method. The optical purity is 99.9 percent or above, and the product quality of the (S)-4-hydroxy-2 oxo-1-pyrrolidine acetamide crystal from II is greatly improved.