887752-13-8 Usage
Description
7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid, also known as 7(S),17(S)-hydroxy DPA, is a novel oxylipin derived from C22 polyunsaturated fatty acids. It is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Similar to Protectin D1, a DHA-derived dihydroxy fatty acid with potent anti-inflammatory activities, 7(S),17(S)-hydroxy DPA is expected to exhibit similar properties, although its biological activity has yet to be determined.
Uses
Used in Pharmaceutical Industry:
7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid is used as a potential anti-inflammatory agent for its expected similarity to the potent anti-inflammatory activities of Protectin D1. Its role in modulating inflammation and immune responses could make it a promising candidate for the development of therapeutics targeting various inflammatory conditions.
Used in Research Applications:
In the field of biological research, 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid serves as a valuable compound for studying the biological activity and mechanisms of action of docosanoids. This can contribute to a better understanding of the roles these molecules play in inflammation and other physiological processes, potentially leading to the discovery of new therapeutic targets and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 887752-13-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,7,7,5 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 887752-13:
(8*8)+(7*8)+(6*7)+(5*7)+(4*5)+(3*2)+(2*1)+(1*3)=228
228 % 10 = 8
So 887752-13-8 is a valid CAS Registry Number.
887752-13-8Relevant articles and documents
Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase
Dobson, Eleanor P.,Barrow, Colin J.,Kralovec, Jaroslav A.,Adcock, Jacqui L.
, p. 1439 - 1447 (2013/06/26)
Resolvins and protectins are important anti-infl ammatory and pro-resolution compounds derived from the enzymatic oxidation of omega-3 fatty acids all -cis -5,8,11,14,17- eicosapentaenoic acid (EPA) and all -cis -4,7,10,13,16,19-docosahexaenoic acid (DHA). We have developed a simple, controlled method to synthesize an array of resolvin and protectin analogs from fatty acid starting materials using soybean 15-lipoxygenase. The conditions were optimized for the production of both mono- and dihydroxy derivatives, with enzyme concentration and pH found to have a signifi cant effect on the reaction products. The methods were applied to fi ve biologically important omega-3 and omega-6 fatty acid substrates. Mono- and dihydroxy compounds were successfully synthesized from all substrates and the products were characterized by normal phase (NP) HPLC , GC-MS, TOF-MS, UV-visible (UV-vis) spectroscopy, and NMR spectroscopy. The methods could be further applied to any polyunsaturated fatty acids containing the cis -1,4,7,10-undecatetraene moiety to produce a range of novel compounds with potential biological activity. Copyright
