888-54-0Relevant articles and documents
Removal of acrolein from active pharmaceutical ingredients using aldehyde scavengers
Kecili, Rustem,Nivhede, David,Billing, Johan,Leeman, Mats,Sellergren, Boerje,Yilmaz, Ecevit
, p. 1225 - 1229 (2012)
A variety of chemical compounds, intermediates, and reagents are used during the process of synthesizing active pharmaceutical ingredients (APIs). Some of these chemicals, intermediates, and reagents, as well as byproducts of synthetic processes, can have toxic properties and be present as impurities at low levels in the API or final drug formulation. If present at high concentrations, the toxic impurities could cause adverse health effects in humans. This paper describes a simple and rapid approach for selective removal of acrolein from APIs using iodixanol as a model API. Several scavengers were tested, and the resins which showed highest binding efficiency and selectivity were chosen for further evaluations. The kinetics of acrolein scavenging in the presence of the API iodixanol and the scavenging capacity of resins were demonstrated in this paper. The most complete scavenging is obtained with PS-NH2 which removes 97.8% of acrolein without any substantial removal of the API during 20 min of reaction time.
Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry
Muguruma, Kyohei,Pradipta, Ambara R.,Ode, Yudai,Terashima, Kazuki,Michiba, Hiroyuki,Fujii, Motoko,Tanaka, Katsunori
, (2020/11/20)
Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy.
Ammonium chlorochromate adsorbed on alumina: A new reagent for the oxidation of alcohols and benzoins to the corresponding carbonyl compounds
Zhang, Gui-Sheng,Shi, Qi-Zeng,Chen, Mi-Feng,Cai, Kun
, p. 953 - 956 (2007/10/03)
A new reagent, ammonium chlorochromate adsorbed on alumina, suitable for the oxidation of alcohols and benzoins to the corresponding carbonyl compounds is described.
