888-79-9

Basic information

• Product Name: 4-AMINO-N-(2-CHLOROPHENYL)BENZAMIDE
• Synonyms: 4-AMINO-N-(2-CHLOROPHENYL)BENZAMIDE;OTAVA-BB 1133762;UKRORGSYN-BB BBV-022987;benzamide, 4-amino-N-(2-chlorophenyl)-;4-amino-N-(2-chlorophenyl)benzamide(SALTDATA: FREE)
• CAS NO: 888-79-9
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.7
• Mol File: 888-79-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 344.3°C at 760 mmHg
• Flash Point: 162°C
• Appearance: /
• Density: 1.351g/cm³
• Vapor Pressure: 6.64E-05mmHg at 25°C
• Refractive Index: 1.692
• CAS DataBase Reference: 4-AMINO-N-(2-CHLOROPHENYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-N-(2-CHLOROPHENYL)BENZAMIDE(888-79-9)
• EPA Substance Registry System: 4-AMINO-N-(2-CHLOROPHENYL)BENZAMIDE(888-79-9)

Safety Data

• Hazardous Substances Data: 888-79-9(Hazardous Substances Data)

Usage

General Description

4-AMINO-N-(2-CHLOROPHENYL)BENZAMIDE is a chemical compound with the molecular formula C13H11ClN2O. It is an organic compound that belongs to the class of benzamides. This chemical is a white to off-white solid and is slightly soluble in water. 4-AMINO-N-(2-CHLOROPHENYL)BENZAMIDE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used in research and development as a reagent in chemical reactions. In addition, it may have potential applications in the pharmaceutical industry as a drug candidate or precursor for the synthesis of bioactive compounds.

InChI:InChI=1/C13H11ClN2O/c14-11-3-1-2-4-12(11)16-13(17)9-5-7-10(15)8-6-9/h1-8H,15H2,(H,16,17)

Upstream product

• 2585-28-6 N-(2-chlorophenyl)-4-nitrobenzamide 
• 95-51-2 o-chloroaniline 
• 62-23-7 4-nitro-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 
• 66493-39-8 4-(N-tert-butoxycarbonyl)aminobenzoic acid 

Downstream Products

• 1158838-41-5 4-((2-chloro-5-fluoropyrimidin-4-yl)amino)-N-(2-chlorophenyl)benzamide 
• 1447816-84-3 N-(2-chlorophenyl)-4-[(1,1-dioxidobenzo[d]isothiazol-3-yl)amino]benzamide 

Relevant articles and documents

Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors

The Aurora kinases are a family of serine/threonine kinases that interact with components of the mitotic apparatus and serve as potential therapeutic targets in oncology. Herein, we reported a series of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl with selective inhibition of Aurora A in either enzymatic assays or cellular phenotypic assays, and displaying more potent anti-proliferation compared with that of VX-680. The most potent compound 10a forms better interaction with Aurora A than Aurora B in molecular docking. Mechanistic studies revealed that 10a disrupt the spindle formation, block the cell cycle progression in the G2/M phase and induce apoptosis in HeLa cell. These results suggested that the produced series of compounds are potential anticancer agents for further development as selective Aurora A inhibitors.

AMIDO-SUBSTITUTED AZOLE COMPOUNDS

The present invention relates to compounds of general formula (I), in which X1, X2, R1, R2, R4, R5, R7, and R8 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.

Virtual screening and synthesis of new chemical scaffolds as VEGFR-2 kinase inhibitors

Background: VEGFR-2 tyrosine kinase inhibitors are currently receiving high interest in drug discovery process as anticancer agents. We have used virtual screening techniques in order to discover new scaffolds that can be used for developing new VEGFR-2 k