88809-35-2

Basic information

• Product Name: 1,3-Diazaspiro[4.5]decane-2,4-dione, 8-methyl-, cis-
• CAS NO: 88809-35-2
• Molecular Formula: C9H14N2O2
• Molecular Weight: 182.222
• Mol File: 88809-35-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3-Diazaspiro[4.5]decane-2,4-dione, 8-methyl-, cis-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diazaspiro[4.5]decane-2,4-dione, 8-methyl-, cis-(88809-35-2)
• EPA Substance Registry System: 1,3-Diazaspiro[4.5]decane-2,4-dione, 8-methyl-, cis-(88809-35-2)

Safety Data

• Hazardous Substances Data: 88809-35-2(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 589-92-4 1-methylcyclohexan-4-one 
• 461-37-0 2,2,2-trifluoroethyl carbamate 
• 506-87-6 ammonium carbonate 
• 151-50-8 potassium cyanide 

Downstream Products

• 69164-35-8 1-amino-4-methyl-cyclohexanecarboxylic acid 
• 1361251-56-0 3-[(9,10-dihydro-9,10-dioxo-2-anthracenyl)sulfonyl]-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1202159-90-7 3-(4-chlorophenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1361251-52-6 8-methyl-3-(4-methylphenylsulfonyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1361251-54-8 3-(4-methoxyphenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1202158-76-6 3-(4-bromophenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1361251-53-7 8-methyl-3-(4-nitrophenylsulfonyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 16252-93-0 3-amino-8-methyl-1,3-diaza-spiro[4.5]decane-2,4-dione 
• 199330-70-6 1-[(1-tert-Butoxycarbonylamino-4-methyl-cyclohexanecarbonyl)-amino]-4-methyl-cyclohexanecarboxylic acid methyl ester 
• 199330-69-3 1-tert-Butoxycarbonylamino-4-methyl-cyclohexanecarboxylic acid 

Relevant articles and documents

An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries

An approach to the parallel synthesis of hydantoin libraries by reaction of in situ generated 2,2,2-trifluoroethylcarbamates and α-amino esters was developed. To demonstrate utility of the method, a library of 1158 hydantoins designed according to the lead-likeness criteria (MW 200-350, cLogP 1-3) was prepared. The success rate of the method was analyzed as a function of physicochemical parameters of the products, and it was found that the method can be considered as a tool for lead-oriented synthesis. A hydantoin-bearing submicromolar primary hit acting as an Aurora kinase A inhibitor was discovered with a combination of rational design, parallel synthesis using the procedures developed, in silico and in vitro screenings.

Synthesis, characterization, and hypoglycemic activity of 3-(arylsulfonyl)spiroimidazolidine-2,4-diones

Spiroimidazolidine-2,4-diones were prepared from methylcyclohexanones by the Bucherer-Bergs reaction. Synthesis of the target 3-(arylsulfonyl) spiroimidazolidine-2,4-diones was achieved by reaction of arylsulfonyl chlorides with corresponding spiroimidazolidine-2,4-diones. The synthesis was confirmed by spectroanalytical techniques and the crystal structure of 3-(4-methoxyphenylsulfonyl)-6-methyl-1,3-diazaspiro[4.5]decane-2,4-dione, and the purity was checked by GC-MS analysis. The in-vivo hypoglycemic potential of 6-methyl-, 7-methyl-, and 8-methyl-3-(4-methylphenylsulfonyl)-1,3-diazaspiro[4. 5]decane-2,4-dione was investigated on male albino rats. The screened compounds were found to have excellent hypoglycemic activity. 6-Methyl-3-(4- methylphenylsulfonyl)-1,3-diazaspiro[4.5]decane-2,4-dione was found highly active, reducing the blood glucose level by 60.79% compared with 41.60% by the standard (glipizide) at a dose level of 100 mg/kg of the mice body weight. The 8-methyl isomer was also more potent than the standard, with 48.56% reduction in blood glucose level.