888298-12-2

Basic information

• Product Name: 3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol
• Synonyms: 3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol
• CAS NO: 888298-12-2
• Molecular Weight: 265.471
• Mol File: 888298-12-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol(888298-12-2)
• EPA Substance Registry System: 3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol(888298-12-2)

Safety Data

• Hazardous Substances Data: 888298-12-2(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 14593-04-5 3-amino-3-phenyl-1-propanol 

Downstream Products

• 357434-56-1 (R)-3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol 

Relevant articles and documents

Lipase-catalyzed resolution of chiral 1,3-amino alcohols: application in the asymmetric synthesis of (S)-dapoxetine

The enzymatic resolution of 3-amino-3-phenylpropan-1-ol derivatives has been studied through acylation processes. Candida antarctica lipase A (CAL-A) has been identified as the best biocatalyst for the transesterification reaction of 3-amino-3-phenyl-1-tert-butyldimethylsilyloxy-propan-1-ol using ethyl methoxyacetate as acylating agent and tert-butyl methyl ether as solvent. This enzymatic study has allowed us to obtain a valuable intermediate for the production of (S)-dapoxetine, which has been synthesized in good overall yield and high enantiomeric excess.