888321-36-6Relevant articles and documents
Pd-catalyzed reductive cleavage of N-N bond in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates with PMHS: Application to a formal enantioselective synthesis of (R)-sitagliptin
Dey, Soumen,Gadakh, Sunita K.,Ahuja, Brij Bhushan,Kamble, Sanjay P.,Sudalai, Arumugam
, p. 684 - 687 (2016)
An environmentally benign approach involving Pd-catalyzed reductive N-N bond cleavage in dibenzyl-1-alkylhydrazine-1,2-dicarboxylates leading to the synthesis of N-(tert-butoxy)carbamates under very mild conditions has been described. PMHS serves as an inexpensive source of hydride in MeOH/deionized H2O medium. This protocol has been successfully applied in the formal synthesis of (R)-sitagliptin, an anti-diabetic drug.
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors
Cox, Jason M.,Harper, Bart,Mastracchio, Anthony,Leiting, Barbara,Sinha Roy, Ranabir,Patel, Reshma A.,Wu, Joseph K.,Lyons, Kathryn A.,He, Huaibing,Xu, Shiyao,Zhu, Bing,Thornberry, Nancy A.,Weber, Ann E.,Edmondson, Scott D.
, p. 4579 - 4583 (2008/02/11)
Substituted 3-aminopiperidines 3 were evaluated as DPP-4 inhibitors. The inhibitors showed good DPP-4 potency with superb selectivity over other peptidases (QPP, DPP8, and DPP9). Selected DPP-4 inhibitors were further evaluated for their hERG potassium ch
FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
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Page/Page column 29, (2010/11/08)
The present invention is directed to novel substituted fused aminopipeiridines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in wh
