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888327-28-4

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888327-28-4 Usage

General Description

Methyl 4-amino-2,3-dihydro-1H-indene-2-carboxylate is a chemical compound with the molecular formula C12H13NO2. It is a carboxylate ester that contains an amino group and a dihydroindene ring. methyl 4-amino-2,3-dihydro-1H-indene-2-carboxylate has potential biological activity and may be used in the synthesis of other organic compounds. It can also be used as a building block for the development of pharmaceuticals and agrochemicals. Additionally, it may have applications in the field of organic synthesis and chemical research. Overall, methyl 4-amino-2,3-dihydro-1H-indene-2-carboxylate is a versatile compound with various potential uses in the chemical and pharmaceutical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 888327-28-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,8,3,2 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 888327-28:
(8*8)+(7*8)+(6*8)+(5*3)+(4*2)+(3*7)+(2*2)+(1*8)=224
224 % 10 = 4
So 888327-28-4 is a valid CAS Registry Number.

888327-28-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 4-amino-2,3-dihydro-1H-indene-2-carboxylate

1.2 Other means of identification

Product number -
Other names methyl-4-aminoindane-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:888327-28-4 SDS

888327-28-4Relevant articles and documents

Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)

Hahn, Michael G.,Lampe, Thomas,El Sheikh, Sherif,Griebenow, Nils,Woltering, Elisabeth,Schlemmer, Karl-Heinz,Dietz, Lisa,Gerisch, Michael,Wunder, Frank,Becker-Pelster, Eva-Maria,Mondritzki, Thomas,Tinel, Hanna,Knorr, Andreas,Kern, Armin,Lang, Dieter,Hueser, Joerg,Schomber, Tibor,Benardeau, Agnes,Eitner, Frank,Truebel, Hubert,Mittendorf, Joachim,Kumar, Vijay,Van Den Akker, Focco,Schaefer, Martina,Geiss, Volker,Sandner, Peter,Stasch, Johannes-Peter

, p. 5323 - 5344 (2021/05/06)

Herein we describe the discovery, mode of action, and preclinical characterization of the soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of cyclic guanosine monophoshphate, is a key regulator of body and tissue homeostasis. sGC activators with their unique mode of action are activating the oxidized and heme-free and therefore NO-unresponsive form of sGC, which is formed under oxidative stress. The first generation of sGC activators like cinaciguat or ataciguat exhibited limitations and were discontinued. We overcame limitations of first-generation sGC activators and identified a new chemical class via high-throughput screening. The investigation of the structure-activity relationship allowed to improve potency and multiple solubility, permeability, metabolism, and drug-drug interactions parameters. This program resulted in the discovery of the oral sGC activator runcaciguat (compound 45, BAY 1101042). Runcaciguat is currently investigated in clinical phase 2 studies for the treatment of patients with chronic kidney disease and nonproliferative diabetic retinopathy.

SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS PPAR MODULATORS FOR THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS

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Page/Page column 15-16, (2008/12/07)

Disclosed herein are new methods of treatment of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and other fibrotic diseases of the liver in a subject by modulating PPARδ with sulfonyl-substituted bicyclic compounds and co

Salts of Modulators Of PPAR and Methods of Treating Metabolic Disorders

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Page/Page column 12, (2010/11/26)

Salt forms of potent modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

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