88839-24-1

Basic information

• Product Name: ethyl-4-<2-(1-tosyl-3,4,4-trimethyl)imidazolidinyl>-2,2-dimethyl-3-oxo-butanoate
• CAS NO: 88839-24-1
• Molecular Weight: 424.561
• Mol File: 88839-24-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl-4-<2-(1-tosyl-3,4,4-trimethyl)imidazolidinyl>-2,2-dimethyl-3-oxo-butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl-4-<2-(1-tosyl-3,4,4-trimethyl)imidazolidinyl>-2,2-dimethyl-3-oxo-butanoate(88839-24-1)
• EPA Substance Registry System: ethyl-4-<2-(1-tosyl-3,4,4-trimethyl)imidazolidinyl>-2,2-dimethyl-3-oxo-butanoate(88839-24-1)

Safety Data

• Hazardous Substances Data: 88839-24-1(Hazardous Substances Data)

Upstream product

• 597-04-6 ethyl 2,2-dimethyl-3-oxobutanoate 
• 71254-91-6 1-tosyl-3,4,4-trimethyl-Δ²-imidazolinium iodide 

Downstream Products

• 100942-52-7 ethyl(Z)-5-(3,4-dimethoxyphenylamino)-2,2-dimethyl-3-oxo-4-pentenoate 
• 88839-20-7 3,3-dimethyl-5,6-dehydro-1-(3,4-dimethoxyphenethyl)pyperidine-2,4-dione 
• 100942-48-1 ethyl (E)-5-<2-(tosylamino-1,1-dimethyl)ethyl methyl>amino-2,2-dimethyl-3-oxo-4-pentenoate 

Relevant articles and documents

MODELS OF FOLATE COENZYMES 13. SYNTHESES OF BENZOQUINOLIZINE AND INDOLOQUINOLIZINE DERIVATIVES VIA CARBON FRAGMENT TRANSFER FROM FLOATE COENZYME MODELS

Anions of β,β-disubstituted acetyl acetates (2, CH2COCR1R2COOR3; R1=R2=Me2, R1=Et, R2=COOMe, R1=Et, R2=SPh) add to 1-tosyl-3,4,4-trimethyl-Δ-imidazolinium iodide (3) to give the corresponding imidazolines (4), which are regarded as models of methylenetetrahydrofolate.These models transfer C(2) of the imidazalodine -with its appended carbon fragment- to tryptamine and 2-(3,4-dimethoxybenzene)ethyl amine to yield enaminoketo ester intermediates which can be converted into benzoquinolizine and indoloquinolizine derivatives, respectively, in two cyclization steps.The intermediate derived from transfer of carbon fragment =CH-CH2COC(SPh)(Et)COOMe to tryptamine exhibits reactions which involve nucleophilic displacement at a sulphur atom of a thio ether bond.