888485-45-8Relevant articles and documents
Desymmetrization of cyclic anhydrides using dihydroxy compounds: Selective synthesis of macrocyclic tetralactones
Muthusamy, Sengodagounder,Gnanaprakasam, Boopathy,Suresh, Eringathodi
, p. 1913 - 1916 (2007/10/03)
The desymmetrization of cyclic anhydrides is carried out using dihydroxy compounds. A mild route to synthesize fused saturated/unsaturated macrocyclic tetralactones with different ring sizes (20-34) having a wide variety of spacers is described. The structure is confirmed by the representative single-crystal X-ray analysis. The multiple reduction of unsaturated macrocyclic tetralactones is also illustrated. This method is mild, selective, and efficient and achieves high yield.