88881-74-7 Usage
General Description
Ethyl 2-(4-acetamidophenyl)sulfonylacetate is a chemical compound that belongs to the class of sulfonamide derivatives, which are known for their wide range of biological and pharmaceutical activities. This particular compound is a sulfonylacetate derivative with a phenyl and acetamido substituent at the 2 and 4 positions, respectively. It is commonly used in the synthesis of pharmaceutical intermediates and has shown potential as an anti-inflammatory, analgesic, and antipyretic agent. Additionally, it has been studied for its potential use in the treatment of various medical conditions, including pain, inflammation, and fever. Overall, Ethyl 2-(4-acetamidophenyl)sulfonylacetate is a versatile compound with potential applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 88881-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,8,8 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 88881-74:
(7*8)+(6*8)+(5*8)+(4*8)+(3*1)+(2*7)+(1*4)=197
197 % 10 = 7
So 88881-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO5S/c1-3-18-12(15)8-19(16,17)11-6-4-10(5-7-11)13-9(2)14/h4-7H,3,8H2,1-2H3,(H,13,14)
88881-74-7Relevant articles and documents
Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus
Wang, Juan,Ansari, Mohammad Fawad,Zhou, Cheng-He
, (2021/04/12)
A class of structurally unique para-aminobenzenesulfonyl oxadiazoles as new potential antimicrobial agents was designed and synthesized from acetanilide. Some target para-aminobenzenesulfonyl oxadiazoles showed antibacterial potency. Noticeably, hexyl derivative 8b (MIC = 1 μg/mL) was more active than norfloxacin against drug resistant MRSA. Compound 8b was able to disturb the membrane effectively and intercalate into deoxyribonucleic acid (DNA) to form a steady 8b-DNA complex, which might be responsible for bacterial metabolic inactivation. Molecular docking indicated that 8b could interact with DNA topoisomerase IV through noncovalent interactions to form a supramolecular complex and hinder the function of this enzyme. These results indicated that hexyl derivative 8b deserved further investigation as a new lead compound.
