888952-51-0Relevant articles and documents
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
Frost, Jennifer M.,Degoey, David A.,Shi, Lei,Gum, Rebecca J.,Fricano, Meagan M.,Lundgaard, Greta L.,El-Kouhen, Odile F.,Hsieh, Gin C.,Neelands, Torben,Matulenko, Mark A.,Daanen, Jerome F.,Pai, Madhavi,Ghoreishi-Haack, Nayereh,Zhan, Cenchen,Zhang, Xu-Feng,Kort, Michael E.
, p. 3373 - 3391 (2016/05/19)
The genetic validation for the role of the Nav1.7 voltage-gated ion channel in pain signaling pathways makes it an appealing target for the potential development of new pain drugs. The utility of nonselective Nav blockers is often li
Therapeutic pyrazolo[3,4-B]pyridines and indazoles
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Page/Page column 15-16, (2008/06/13)
The present invention provides for compounds of Formula I: wherein R2, R3, R4, R5, R6, R7, X, and L have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of central nervous disorders and conditions including attention deficit hyperactivity disorder, neuropathic pain, urinary incontinence, anxiety, depression, and schizophrenia and fibromyalgia. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.