88899-56-3

Basic information

• Product Name: BAFILOMYCIN B1
• Synonyms: BAFILOMYCIN B1;BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES;BafilomycinB1fromStreptomycesgriseus;bafilomycin b1from streptomyces sp.;37-De(carboxy)-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methylhygrolidin;hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)am;ino)carbonyl)-2-methoxy-24-methyl-
• CAS NO: 88899-56-3
• Molecular Formula: C44H65NO13
• Molecular Weight: 815.99
• Product Categories: MacrolidesMore...Close...;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;AntifungalAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Mechanism of Action;Spectrum of Activity;Antibiotic
• Mol File: 88899-56-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 939.4 ºC
• Flash Point: 521.9ºC
• Appearance: faint yellow to yellow/
• Density: 1.22 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: −20°C
• BRN: 4640118
• CAS DataBase Reference: BAFILOMYCIN B1(CAS DataBase Reference)
• NIST Chemistry Reference: BAFILOMYCIN B1(88899-56-3)
• EPA Substance Registry System: BAFILOMYCIN B1(88899-56-3)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 36/37/39-45
• RIDADR: UN 3462 6.1/PG 1
• WGK Germany: 3
• RTECS: NG8841000
• F: 10-21
• HazardClass: 3
• Hazardous Substances Data: 88899-56-3(Hazardous Substances Data)

Usage

Description

Bafilomycin B1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is a potent macrocyclic lactone with a broad range of activity against bacteria, fungi, insects, nematodes, and protozoans. Bafilomycin B1 inhibits the activity of rat liver lysosomal vacuolar H+-ATPase (V-ATPase) in a concentration-dependent manner and has attracted interest as a potential agent for treating osteoporosis.

Uses

Used in Pharmaceutical Industry:
Bafilomycin B1 is used as an antimicrobial agent for its broad-spectrum activity against various microorganisms, including bacteria, fungi, insects, nematodes, and protozoans.
Used in Neuroprotection:
Bafilomycin B1 is used as a neuroprotective agent for inhibiting chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) when used at a concentration of 1 nM.
Used in Antiviral Applications:
Bafilomycin B1 is used as an antiviral agent for reducing viral genome copy numbers in the culture supernatant of Vero E6 cells infected with H1N1 influenza A.
Used in Autophagy Research:
Bafilomycin B1 is used as a research tool for inducing autophagosome accumulation in MCF-7 cells at concentrations ranging from 10-1,000 nM, which helps in studying the process of autophagy and its role in various diseases.
Used in Osteoporosis Treatment:
Bafilomycin B1 is used as a potential agent for treating osteoporosis, as it has attracted interest for its potential therapeutic effects on bone health.

InChI:InChI=1/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12-,18-17+,24-13-,25-20-,34-21-/t26-,27+,28-,29-,30-,33-,35+,39-,40+,41+,42?,44+/m0/s1

Downstream Products

• 65518-38-9 N-(3-hydroxy-2-cyclopentenone-2-yl)-fumaric acid monoamide