88909-96-0Relevant articles and documents
Synthesis and photophysical properties of multichromophoric carbonyl-bridged triarylamines
Haedler, Andreas T.,Beyer, Sebastian R.,Hammer, Natalie,Hildner, Richard,Kivala, Milan,K?hler, Jürgen,Schmidt, Hans-Werner
, p. 11708 - 11718 (2014)
The synthesis and photophysical properties of two novel multichromophoric compounds is presented. Their molecular design comprises a carbonyl-bridged triarylamine core and either naphthalimides or 4-(5-hexyl-2,2 -bithiophene)naphthalimides as second chrom
Target Enzyme-Activated Two-Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two-Dimensional Design Strategy
Ning, Jing,Wang, Wei,Ge, Guangbo,Chu, Peng,Long, Feida,Yang, Yongliang,Peng, Yulin,Feng, Lei,Ma, Xiaochi,James, Tony D.
supporting information, p. 9959 - 9963 (2019/06/24)
The rapid development of fluorescent probes for monitoring target enzymes is still a great challenge owing to the lack of efficient ways to optimize a specific fluorophore. Herein, a practical two-dimensional strategy was designed for the development of an isoform-specific probe for CYP3A4, a key cytochrome P450 isoform responsible for the oxidation of most clinical drugs. In first dimension of the design strategy, a potential two-photon fluorescent substrate (NN) for CYP3A4 was effectively selected using ensemble-based virtual screening. In the second dimension, various substituent groups were introduced into NN to optimize the isoform-selectivity and reactivity. Finally, with ideal selectivity and sensitivity, NEN was successfully applied to the real-time detection of CYP3A4 in living cells and zebrafish. These findings suggested that our strategy is practical for developing an isoform-specific probe for a target enzyme.
Structures of bifunctional molecules containing two very different supramolecular synthons: Carboxylic acid and strong π...π stacking 1,8-naphthalimide ring
Reger, Daniel L.,Debreczeni, Agota,Horger, Jacob J.,Smith, Mark D.
scheme or table, p. 4068 - 4079 (2012/03/13)
A series of molecules containing a carboxylic acid and a 1,8-naphthalimide group joined by different linkers (HLC1 = CH2; HL C2 = CH2CH2; HLC3 = CH 2CH2CH2;