89-47-4

Basic information

• Product Name: menthyl valerate
• Synonyms: rel-3-Methylbutanoic acid (1S*)-2β*-isopropyl-5α*-methylcyclohexane-1α*-yl ester;Butanoic acid, 3-methyl-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, rel-;Butanoic acid, 3-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, (1alpha,2beta,5alpha)-;Einecs 201-910-2
• CAS NO: 89-47-4
• Molecular Formula: C15H28O2
• Molecular Weight: 240.38
• EINECS: 201-910-2
• Mol File: 89-47-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 278.7°C at 760 mmHg
• Flash Point: 128.9°C
• Appearance: /
• Density: 0.906-0.908
• Vapor Pressure: 0.00419mmHg at 25°C
• Refractive Index: 1.454
• CAS DataBase Reference: menthyl valerate(CAS DataBase Reference)
• NIST Chemistry Reference: menthyl valerate(89-47-4)
• EPA Substance Registry System: menthyl valerate(89-47-4)

Safety Data

• Hazardous Substances Data: 89-47-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid; sweet herbaceous aroma.

InChI:InChI=1/C15H28O2/c1-5-6-7-15(16)17-14-10-12(4)8-9-13(14)11(2)3/h11-14H,5-10H2,1-4H3

Upstream product

• 503-74-2 3-methylbutyric acid 
• 2216-51-5 (-)-menthol 
• 108-12-3 isopentanoyl chloride 
• 201230-82-2 carbon monoxide 
• 89-78-1 menthol 
• 115-11-7 isobutene 

Relevant articles and documents

Synthesis of L-menthyl isovalerate by esterification of isovaleric acid with L-menthol under microwave irradiation

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Hydroxycarbonylation of isobutylene in the presence of the palladium acetylacetonate-triphenylphosphine-p-toluenesulfonic acid catalyst system

The reaction of isobutylene hydroxycarbonylation with carbon monoxide and an alcohol (ethanol, 1-menthol) in the presence of the palladium acetylacetonate-triphenylphosphine-p-toluenesulfonic acid catalytic system was investigated. It was shown that the reaction proceeds regioselectively with the formation of linear products (ethyl isovalerate, 1-menthyl isovalerate). The optimum conditions for running the process were found, at which the yield of the main products is 67-79%.

Topical menthol, or a related cooling compound, to induce lubrication

Vaginal Lubrication is an important component of a woman's sexual arousal. The other components are vaginal vasocongestion and the establishment of a clitoral erection. The use of menthol or any related cooling compound, topically applied to the clitoris, evokes a reflex vaginal lubrication, via the clitoral nociceptors, the spinal autonomic nerves, and inducing the reflex release of vasoactivepolypeptides adjacent to the vaginal arterioles. The vaginal lubrication can be an effective therapy for atrophic vaginitis, the most common cause of dyspareunia (pain with intercourse).