890-29-9

Basic information

• Product Name: (4-Methylphenyl)(1H-indole-3-yl) ketone
• Synonyms: (4-Methylphenyl)(1H-indole-3-yl) ketone;1H-Indol-3-yl(p-tolyl) ketone;3-(4-Methylbenzoyl)-1H-indole;3-(4-Methylbenzoyl)indole
• CAS NO: 890-29-9
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.28
• Mol File: 890-29-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 179-181 °C
• Boiling Point: 450.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.198±0.06 g/cm3(Predicted)
• PKA: 15.28±0.30(Predicted)
• CAS DataBase Reference: (4-Methylphenyl)(1H-indole-3-yl) ketone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Methylphenyl)(1H-indole-3-yl) ketone(890-29-9)
• EPA Substance Registry System: (4-Methylphenyl)(1H-indole-3-yl) ketone(890-29-9)

Safety Data

• Hazardous Substances Data: 890-29-9(Hazardous Substances Data)

Usage

General Description

(4-Methylphenyl)(1H-indole-3-yl) ketone is a chemical compound with the molecular formula C20H17NO. It is a ketone derivative that contains a 4-methylphenyl group and a 1H-indole-3-yl group. (4-Methylphenyl)(1H-indole-3-yl) ketone has potential applications in pharmaceutical and medicinal chemistry, as indole derivatives are known for their diverse biological activities, including anticancer, anti-inflammatory, and antibacterial properties. The 4-methylphenyl group can also contribute to the compound's pharmacological profile. Further research and studies may be necessary to fully understand the properties and potential uses of this chemical.

Upstream product

• 120-72-9 indole 
• 59046-28-5 p-toluoyl-1H-1,2,3-benzotriazole 
• 99-94-5 p-Toluic acid 
• 15818-64-1 N-(4-methylbenzyl)aniline 
• 104-85-8 para-methylbenzonitrile 
• 1147847-48-0 C₃₀H₃₀N₄S 
• 68-12-2 N,N-dimethyl-formamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 1033133-17-3 potassium oxo-(4-methylphenyl)acetate 
• 14062-19-2 p-tolylacetic acid ethyl ester 

Relevant articles and documents

Palladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation

Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles has been accomplished using a readily available arene at moderate temperature. The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications are the important practical features.

Decarboxylative acylation of: N -free indoles enabled by a catalytic amount of copper catalyst and liquid-assisted grinding

A facile decarboxylative acylation of N-free indoles with α-ketonates via liquid-assisted grinding was reported. The reaction requires only a catalytic amount of Cu(OAc)2·H2O in combination with O2 as the terminal oxidant to give various 3-acylindoles with high efficiency. Additionally, this new methodology was applicable to a gram-scale synthesis.

A novel microwave-irradiated solvent-free 3-acylation of indoles on alumina

A simple and efficient 3-acylation of indoles under microwave-heated and solvent-free conditions is developed. This general procedure uses neutral Al2O3 as a new, green and reusable catalyst giving good to high yields within short reaction times. Utilizing such an environmentally- benign methodology, a variety of indoles bearing electron-releasing or electron-withdrawing groups were conveniently acylated.