890005-22-8

Basic information

• Product Name: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE
• Synonyms: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE;AKOS BBS-00002818;3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE;3-TrifluoroMethyl-4,5,6,7-tetrahydroindazole;4,5,6,7-Tetrahydro-3-(trifluoroMethyl)-indazole;4,5,6,7-Tetrahydro-3-(trifluoromethyl)-2H-indazole;3-TrifluoroMethyl-4,5,6,7-tetrahydro-2H-indazole
• CAS NO: 890005-22-8
• Molecular Formula: C₈H₉F₃N₂
• Molecular Weight: 190.17
• Mol File: 890005-22-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 121°C
• Boiling Point: 255.6±35.0℃ (760 Torr)
• Flash Point: 108.4±25.9℃
• Appearance: /
• Density: 1.345±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE(890005-22-8)
• EPA Substance Registry System: 4,5,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)-1H-INDAZOLE(890005-22-8)

Safety Data

• Hazardous Substances Data: 890005-22-8(Hazardous Substances Data)

Upstream product

• 56734-75-9 2-pentafluoroethyl-cyclohexanone 
• 387-89-3 2-(2,2,2-trifluoroacetyl)cyclohexanone 
• 658-78-6 1-nitro-4-trifluoroacetoxy-benzene 
• 108-94-1 cyclohexanone 
• 6425-41-8 N-cyclohexylmorpholine 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 950785-30-5 {4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}acetonitrile 
• 950785-31-6 1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 950785-45-2 1-(4-bromophenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 950785-44-1 1-(4-iodophenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 57631-05-7 3-(trifluoromethyl)-1H-indazole 
• 1057662-37-9 2-fluoro-4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]benzonitrile 
• 1057662-49-3 1-[2-fluoro-4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 1057662-54-0 1-{3-fluoro-4-[2-oxo-2-(1-pyrrolidinyl)ethyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 1057662-63-1 1-{4-[(1,1-dioxido-2-isothiazolidinyl)methyl]-3-fluorophenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 
• 1057662-68-6 1-[3-fluoro-4-(4-morpholinylcarbonyl)phenyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole 

Relevant articles and documents

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.

HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE

Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

Novel polyfluoroalkylated pyrazoles from 2-polyfluoroacylcycloalkanones and hydrazines: Syntheses and unequivocal molecular structure assignment

The reaction between 2-trifluoroacetylcycloalkanones and methylhydrazine or phenylhydrazine exclusively yields 3-CF3-pyrazoles. When the chain length of the polyfluorinated substituent in RFC(O) group increases, 5-RF-pyraz