89017-55-0Relevant articles and documents
LEWIS ACID INDUCED REACTIONS OF PROPARGYL TRIMETHYL SILANE WITH ω-ETHOXY LACTAMS. SYNTHESIS OF γ-ALLENYL-GABA
Hiemstra, Henk,Fortgens, Hendrikus P.,Speckamp, W. Nico
, p. 3115 - 3118 (1984)
Reactions of propargyl trimethyl silane with ω-ethoxy lactams 1a-c under the influence of boron trifluoride etherate afford ω-allenyl lactams 3a-c; 5-allenyl-2-pyrrolidinone is hydrolyzed to γ-allenyl-GABA.
Expedient pyrrolizidine synthesis by propargylsilane addition to N-acyliminium ions followed by gold-catalyzed α-allenyl amide cyclization
Breman, Arjen C.,Dijkink, Jan,Van Maarseveen, Jan H.,Kinderman, Sape S.,Hiemstra, Henk
supporting information; experimental part, p. 6327 - 6330 (2009/12/24)
(Chemical Equation Presented) A reaction sequence, involving the addition of (substituted) propargylsilanes to lactam-derived N-acyliminium ions followed by gold-catalyzed cyclization of the resulting α-allenyl amide, is applied in expedient syntheses of
Process for the production of (S)-vinyl and allenyl gaba
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, (2008/06/13)
The present invention is directed to a new class of pyrrolidinone derivatives that are useful as chemical intermediates in the synthesis of S-allenyl and S-vinyl GABA, both of which are antiepileptic agents.
