89070-00-8

Basic information

• Product Name: Carbamimidothioic acid, [2-(trifluoromethyl)phenyl]-, ethyl ester
• CAS NO: 89070-00-8
• Molecular Formula: C10H11F3N2S
• Molecular Weight: 248.272
• Mol File: 89070-00-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamimidothioic acid, [2-(trifluoromethyl)phenyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamimidothioic acid, [2-(trifluoromethyl)phenyl]-, ethyl ester(89070-00-8)
• EPA Substance Registry System: Carbamimidothioic acid, [2-(trifluoromethyl)phenyl]-, ethyl ester(89070-00-8)

Safety Data

• Hazardous Substances Data: 89070-00-8(Hazardous Substances Data)

Upstream product

• 88-17-5 2-(trifluoromethyl)benzenamine 
• 63494-72-4 N-((2-(trifluoromethyl)phenyl)carbamothioyl)benzamide 
• 1736-71-6 2-trifluoromethylphenyl thiourea 
• 75-03-6 ethyl iodide 

Downstream Products

• 89069-56-7 3-(2-trifluoromethylphenyl)-2-ethylthio-4(3H)-pyrimidinone 

Relevant articles and documents

Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity

S-Ethyl N-phenylisothiourea (4) has been found to be a potent inhibitor of both the human constitutive and inducible isoforms of nitric oxide synthase. A series of substituted N-phenylisothiourea analogues was synthesized to investigate the structure-activity relationship of this class of inhibitor. Each analogue was evaluated for human isoform selectivity. One analogue, S-ethyl N-[4-(trifluoromethyl)phenyl]isothiourea (39), exhibited 115-fold and 29-fold selectivity for the neuronal isoform versus the inducible and endothelial derived constitutive isoforms, respectively. Studies have shown the substituted N-phenylisothiourea 39 binds competitively with L,-arginine.