891-15-6

Basic information

• Product Name: Benzoxazole, 5-chloro-2-(4-methoxyphenyl)-
• CAS NO: 891-15-6
• Molecular Formula: C14H10ClNO2
• Molecular Weight: 259.692
• Mol File: 891-15-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzoxazole, 5-chloro-2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoxazole, 5-chloro-2-(4-methoxyphenyl)-(891-15-6)
• EPA Substance Registry System: Benzoxazole, 5-chloro-2-(4-methoxyphenyl)-(891-15-6)

Safety Data

• Hazardous Substances Data: 891-15-6(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 2393-23-9 4-methoxy-benzylamine 
• 95-55-6 2-amino-phenol 
• 100-07-2 4-methoxy-benzoyl chloride 
• 17200-29-2 5-chloro-benzoxazole 
• 213468-59-8 S-methyl 3-oxo-3-(4-methoxylphenyl)propanedithioate 
• 220464-84-6 (p-chloro-N-phenoxy)phthalimide 
• 36637-30-6 O-(4-chlorophenyl)hydroxylamine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1166839-38-8 4-methoxybenzaldehyde O-4-chlorophenyl oxime 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 29644-84-6 4-Chlor-2-<4-methoxy-benzyliden-amino>-phenol 

Relevant articles and documents

Iron(III) Chloride Mediated para-Selective C-H Functionalization: Access to C5-Chloro and C5,C7-Dichloro/Dianisyl Substituted 2-Arylbenzoxazoles

Iron(III) chloride mediated para-selective C?H chlorination and subsequent annulation of 2-amidophenol to synthesize C5- and C5, C7-chlorinated benzoxazoles was developed. Further, the oxidative cross-dehydrogenative coupling of amidophenol with anisole b

Deep eutectic solvent-catalyzed arylation of benzoxazoles with aromatic aldehydes

A novel and efficient methodology for the arylation of benzoxazoles with aromatic aldehydes catalyzed by deep eutectic solvent has been developed. The reaction smoothly proceeded with a wide range of substrates to give the desired products in high yields within short reaction time. Deep eutectic solvents are easily recovered and reused without significant loss of catalytic activity.

p-Toluenesulfonic acid-catalyzed metal-free formal [4?+?1] heteroannulation via N[sbnd]H/O[sbnd]H/S[sbnd]H functionalization: One-pot access to 2-aryl/hetaryl/alkyl benzazole derivatives

A concise and direct one-pot [4?+?1] synthetic strategy for the construction of 2-substituted benzazoles such as benzoxazoles and benzothiazoles has been disclosed in high yields (80–98%) by cascade coupling reaction of 2-amino(thio)phenols with β-oxodithioesters. The current approach enables N[sbnd]H/O[sbnd]H/S[sbnd]H functionalization in one-pot under solventless condition leading to diverse benzazoles without use of any external metal. A wide range of 2-amino(thio)phenols and β-oxodithioesters are compatible toward this transformation with excellent functional group tolerance. Furthermore, we preempt the wider implications of this novel strategy by demonstrating its compatibility toward versatile diversification of DNA Topoisomerase-II inhibitors.