891143-61-6Relevant articles and documents
Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2′ to P1/P1′
Ax, Anna,Schaal, Wesley,Vrang, Lotta,Samuelsson, Bertil,Hallberg, Anders,Karlén, Anders
, p. 755 - 764 (2005)
Previous studies of HIV protease inhibitors have shown that it is possible to elongate the P1/P1′ sidechains to reach the S3/S3′ binding sites. By analogy, we expected that it would be possible to design inhibitors reaching between the S1/S1′ and S2/S2′ b