89115-54-8Relevant articles and documents
Nickel-Catalyzed Asymmetric Reductive Arylbenzylation of Unactivated Alkenes
Jin, Youxiang,Yang, Haobo,Wang, Chuan
supporting information, p. 2724 - 2729 (2020/04/02)
Herein, we report a nickel-catalyzed asymmetric two-component reductive dicarbofunctionalization of aryl iodide-tethered unactivated alkenes using benzyl chlorides as the challenging coupling partner. This arylbenzylation reaction enables the efficient synthesis of diverse benzene-fused cyclic compounds bearing a quaternary stereocenter with a high tolerance of sensitive functionalities in highly enantioselective manner. The preliminary mechanistic investigations suggest a radical chain reaction mechanism.