89152-85-2

Basic information

• Product Name: C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE
• Synonyms: C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE;[2-(3-Methylphenyl)-1,3-thiazol-4-yl]methylamine;1-[2-(3-methylphenyl)-1,3-thiazol-4-yl]methanamine(SALTDATA: FREE);1-[2-(3-methylphenyl)-1,3-thiazol-4-yl]methanamine;[2-(3-methylphenyl)-1,3-thiazol-4-yl]methanamine;[2-(3-methylphenyl)-4-thiazolyl]methanamine;[2-(3-methylphenyl)thiazol-4-yl]methanamine;[2-(3-methylphenyl)thiazol-4-yl]methylamine
• CAS NO: 89152-85-2
• Molecular Formula: C11H12N2S
• Molecular Weight: 204.29
• Mol File: 89152-85-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 374.173°C at 760 mmHg
• Flash Point: 180.093°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE(89152-85-2)
• EPA Substance Registry System: C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE(89152-85-2)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-37/38-41
• Safety Statements: 26-39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 89152-85-2(Hazardous Substances Data)

Usage

General Description

C-(2-m-Tolyl-thiazol-4-yl)-methylamine is a chemical compound with the molecular formula C11H13N3S. It is a derivative of thiazole that contains a methylamine group attached to the thiazole ring. C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE is used in the pharmaceutical industry for the synthesis of various drugs and active pharmaceutical ingredients. It has also been studied for its potential biological activities and pharmacological properties. Additionally, it is commonly used as a building block in organic synthesis and chemical research. However, it is important to handle this compound with care as it may pose hazards if mishandled or improperly used.

InChI:InChI=1/C11H12N2S/c1-8-3-2-4-9(5-8)11-13-10(6-12)7-14-11/h2-5,7H,6,12H2,1H3

Upstream product

• 41963-17-1 4-chloromethyl-2-m-tolyl-thiazole 
• 2362-63-2 3-methylthiobenzamide 
• 618-47-3 m-toluamide 

Relevant articles and documents

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.