891658-41-6

Basic information

• Product Name: 2-[3-(benzofuran-2-carbonyl)phenyl] propionitrile
• Synonyms: 2-[3-(benzofuran-2-carbonyl)phenyl] propionitrile
• CAS NO: 891658-41-6
• Molecular Weight: 275.307
• Mol File: 891658-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-(benzofuran-2-carbonyl)phenyl] propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(benzofuran-2-carbonyl)phenyl] propionitrile(891658-41-6)
• EPA Substance Registry System: 2-[3-(benzofuran-2-carbonyl)phenyl] propionitrile(891658-41-6)

Safety Data

• Hazardous Substances Data: 891658-41-6(Hazardous Substances Data)

Upstream product

• 271-89-6 1-benzofurane 
• 5537-71-3 2-(3-carboxyphenyl)propanenitrile 

Relevant articles and documents

2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to selected (R)-2-phenyl-propionamides and (R)-2-phenyl-sulfonamides with a hydrogen bond acceptor atom/group in a well defined position in the chemical space. These compounds show a surprising potent inhibitory effect on C5a induced human PMN chemotaxis. The compounds of the invention absolutely lack of CXCL8 inhibitory activity. Said compounds are useful in the treatment of pathologies depending on the chemotactic activation of neutrophils and monocytes induced by the fraction C5a of the complement. In particular, the compounds of the invention are useful in the treatment of sepsis, psoriasis, rheumatoid arthritis, ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of injury caused by ischemia and reperfusion.