891782-60-8

Basic information

• Product Name: 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
• Synonyms: 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;1(2H)-Isoquinolinone, 7-bromo-3,4-dihydro-;7-bromo-3,4-dihydroisoquinolin-1(2H)-one;7-BroMo-3,4-dihydro-1(2H)-isoquinolinone;7-broMo-1,2,3,4-tetrahydroisoquinolin-1-one
• CAS NO: 891782-60-8
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.07
• Mol File: 891782-60-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 438.4 °C at 760 mmHg
• Flash Point: 219 °C
• Appearance: /
• Density: 1.559±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.41±0.20(Predicted)
• CAS DataBase Reference: 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(891782-60-8)
• EPA Substance Registry System: 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(891782-60-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-52
• Hazardous Substances Data: 891782-60-8(Hazardous Substances Data)

Usage

Uses

7-Bromo-3,4-dihydro-2H-isoquinolin-1-one is a useful research chemical.

InChI:InChI=1S/C9H8BrNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-2,5H,3-4H2,(H,11,12)

Upstream product

• 22245-96-1 7-nitro-3,4-dihydro-2H-isoquinolin-1-one 
• 1196-38-9 3,4-dihydroisoquinolin-1(2H)-one 
• 83-33-0 inden-1-one 
• 75-75-2 methanesulfonic acid 
• 14548-39-1 6-bromoindan-1-one 
• 135335-11-4 ethyl <2-(4-bromophenyl)ethyl>carbamate 
• 305447-65-8 methyl 4-(bromophen)ethylcarbamate 
• 73918-56-6 4-Bromophenethylamine 
• 66491-03-0 7-amino-3,4-dihydroisoquinoline-1(2H)-one 

Downstream Products

• 1231891-45-4 7-bromo-2-(4-fluorophenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 17680-55-6 7-bromo-1,2,3,4-tetrahydroisoquinoline 
• 1368661-06-6 7-phenyl-3,4-dihydroisoquinolin-1(2H)-one 
• 952587-40-5 1-oxo-1,2,3,4-tetrahydro-7-isoquinolinecarbaldehyde 

Relevant articles and documents

1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors

Metallo-β-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-negative pathogens. Unfortunately, clinically efficient MBL inhibitors still represent an unmet medical need. We previou

WDR5 INHIBITORS AND MODULATORS

Isoquinolinone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

The present disclosure relates to a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.