89180-50-7

Basic information

• Product Name: 5,6-dichloropyridazin-4-amine
• Synonyms: 5,6-dichloropyridazin-4-amine;5-Amino-3,4-dichloropyridazine
• CAS NO: 89180-50-7
• Molecular Formula: C₄H₃Cl₂N₃
• Molecular Weight: 163.995
• Mol File: 89180-50-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5,6-dichloropyridazin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dichloropyridazin-4-amine(89180-50-7)
• EPA Substance Registry System: 5,6-dichloropyridazin-4-amine(89180-50-7)

Safety Data

• Hazardous Substances Data: 89180-50-7(Hazardous Substances Data)

Usage

General Description

5,6-dichloropyridazin-4-amine is a chemical compound that belongs to the pyridazine class of heterocyclic compounds. It is characterized by the presence of two chlorine atoms and an amino group attached to the pyridazine ring. 5,6-dichloropyridazin-4-amine has potential applications in the field of organic synthesis and pharmaceuticals, as it can be used as a building block for the synthesis of various biologically active molecules. It is important to handle this chemical with caution, as it may pose health and environmental risks if not properly managed and disposed of. Additionally, it is crucial to adhere to safety guidelines and regulations when working with 5,6-dichloropyridazin-4-amine to minimize any potential hazards.

Upstream product

• 6339-19-1 5-amino-4-chloropyridazin-3(2H)-one 
• 14161-11-6 3,4,5-trichloropyridazine 
• 105398-92-3 3,4-dichloro-5-(N,N-dimethylaminomethyleneamino)pyridazine 
• 7664-41-7 ammonia 

Downstream Products

• 111163-92-9 7-chloro-2-phenyl-oxazolo[4,5-d]pyridazine 
• 20744-39-2 4-aminopyridazine 
• 61071-29-2 5-amino-4-chloro-3-hydrazinopyridazine 

Relevant articles and documents

Transformations of N-Heteroarylformamidines and N-Heteroarylformamidine Oximes. New Syntheses and Transformations of Oxazolopyridazines

New syntheses of oxazolopyridazine derivatives 7 and 11 were achieved by the cyclization of substituted N-pyridazin-5-ylformamide oximes 6 and 10.Under mild reaction conditions the transformations of the substituted amino group at position 2 of the oxazolopyridazine system 7 occured to produce the compounds 11, 14, and 15, while under more drastic reaction conditions the nucleophilic attack at carbon at position 2 followed by the ring opening of the oxazole part of the molecule was observed to give the compounds 13, 16, 17 and 18. - Keywords: Cyclization with C-O bond formation; Substituted N-pyridazin-5-ylformamidines and -formamide oximes; Oxazolopyridazines; Ring opening of oxazolopyridazines

Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)

The invention discloses substituted heteroaryl compounds and compositions thereof and their use. The compounds of formula (I) compound or type shown in (I) a compound represented by stereo isomers, tautomers, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or its prodrug. The invention also provides a pharmaceutical composition, the compounds and pharmaceutical compositions can be regulated protein kinase, particularly Aurora kinase and JAK kinase activity, for the prevention, treatment, treatment and reduce protein kinase, in particular JAK kinase activity mediated diseases or disorders. (by machine translation)

Synthesis and anticonvulsant activity of 3H-imidazo[4,5-c]-pyridazine, 1H-imidazo[4,5-d]pyridazine and 1H-benzimidazole analogues of 9-(2-fluorobenzyl)-6-methylamino-9H-purine

The 3H-imidazo[4,5-c]pyridazine, 1H-imidazo[4,5-d]pyridazine, and 1H-benzimidazole analogues of the potent anticonvulsant purine 9-(2-fluorobenzyl)-6-methylamino-9H-purine (1, 78U79) were synthesized and tested for anticonvulsant activity. The 3H-imidazo[4,5-c]pyridazines 8 and 9 were prepared in five stages from 3,4,5-trichloropyridazine (2). The 1H-imidazolo[4,5-d]pyridazine 15 was synthesized in four stages from 5-[(benzyloxy)methyl]-1,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one (10a). The benzimidazole analogues 18 and 20 were prepared from 2,6-dinitroaniline in three stages. These compounds were one-tenth or less as active as 1 in protecting rats against maximal electroshock-induced seizures.