89221-21-6

Basic information

• Product Name: Phenol, 4-(1H-1,2,3-triazol-4-yl)-
• CAS NO: 89221-21-6
• Molecular Formula: C8H7N3O
• Molecular Weight: 161.163
• Mol File: 89221-21-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Phenol, 4-(1H-1,2,3-triazol-4-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-(1H-1,2,3-triazol-4-yl)-(89221-21-6)
• EPA Substance Registry System: Phenol, 4-(1H-1,2,3-triazol-4-yl)-(89221-21-6)

Safety Data

• Hazardous Substances Data: 89221-21-6(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 5301-97-3 4-(4-methoxyphenyl)-1H-[1,2,3]triazole 
• 3179-08-6 4-(2-nitrovinyl)phenol 
• 1680-44-0 5-phenyl-1H-1,2,3-triazole 
• 6111-97-3 5-(4-nitrophenyl)-1H-1,2,3-triazole 
• 5301-97-3 5-(4-methoxyphenyl)-1H-1,2,3-triazole 
• 89221-20-5 4-(4-aminophenyl)-1,2,3-triazole 
• 768-60-5 4-methoxyphenylacetylen 

Relevant articles and documents

Silica immobilized copper N-heterocyclic carbene: An effective route to 1,2,3-triazoles via azide-alkyne cycloaddition and multicomponent click reaction

A new silica supported copper N-heterocyclic carbene (Cu-NHC@SiO2) complex is prepared and characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) analyses. This complex is an efficient and easily retrievable catalyst for 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition reaction as well as one-pot reaction using arylboronic acids. This catalytic system is also suitable for synthesis of 4-aryl-NH-1,2,3-triazoles from diverse benzaldehydes. Further, the catalyst can efficiently be recycled up to fifth cycle for all the three methods of 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition and multi-component reactions.

Method of catalytically synthesizing 4-aryl-NH-1,2,3-triazole derivative under microwave radiation

The invention discloses a method of catalytically synthesizing 4-aryl-NH-1,2,3-triazole derivative under microwave radiation. The method includes the steps of: successively adding substituted 2-nitroolefin, sodium azide, TfOH, and pyridine into a reaction

Recyclable Acid–Base Bifunctional Core–Shell–Shell Nanosphere Catalyzed Synthesis of 5-Aryl-1H-1,2,3-triazoles through the “One-Pot” Cyclization of Aldehydes, Nitromethane, and Sodium Azide

A magnetically separable core–shell–shell nanosphere, Fe3O4@nSiO2-SO3H@MS-NHCOCH3 (n=nonporous, MS=microporous SiO2), was fabricated as an acid–base collaborative catalyst for the three-component cyclization of aromatic aldehydes, nitroalkane, and sodium azide to afford 1H-1,2,3-triazoles. The bifunctional heterogeneous catalyst showed high activity for this transformation and good chemoselectivity, and toxic HN3 was not released during the course of the reaction. A variety of aldehydes were transformed into the corresponding 5-aryl-1H-1,2,3-triazoles in up to 98 % yield. Furthermore, the catalyst could be recovered by using an external magnetic field and reused many times without any loss in activity. In contrast, a homogeneous catalyst system comprising ammonium acetate/acetic acid also worked in this three-component cyclization to afford 1H-1,2,3-triazoles.