89238-74-4

Basic information

• Product Name: (1β,3α,5β)-1,3-Dihydroxy-cholan-24-oic Acid
• Synonyms: (1β,3α,5β)-1,3-Dihydroxy-cholan-24-oic Acid
• CAS NO: 89238-74-4
• Molecular Formula: C₂₄H₄₀O₄
• Molecular Weight: 392.572
• Product Categories: Steroids
• Mol File: 89238-74-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1β,3α,5β)-1,3-Dihydroxy-cholan-24-oic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1β,3α,5β)-1,3-Dihydroxy-cholan-24-oic Acid(89238-74-4)
• EPA Substance Registry System: (1β,3α,5β)-1,3-Dihydroxy-cholan-24-oic Acid(89238-74-4)

Safety Data

• Hazardous Substances Data: 89238-74-4(Hazardous Substances Data)

Usage

Uses

(1β,3α,5β)-1,3-Dihydroxy-cholan-24-oic Acid is a bile acid metabolite. Steroid compound.

Upstream product

• 104854-46-8 1β,3α-dihydroxy-5β-cholan-24-oic acid methyl ester 
• 434-13-9 Lithocholic acid 
• 1553-56-6 dehydrolithocholic acid 
• 91667-86-6 5β cholene-1, one-3, oate-24 de methyle 
• 99598-12-6 methyl 1β-hydroxy-3-oxo-5β-cholan-24-oate 
• 99598-08-0 methyl 1β,2β-epoxy-3-oxo-5β-cholan-24-oate 
• 1452-30-8 3-oxo-5β-chol-1-en-24-oic acid 
• 363136-69-0 2-formyl-3-oxo-5β-chol-1-en-24-oic acid 
• 363136-68-9 2-hydroxymethylene-3-oxo-5β-cholan-24-oic acid 
• 1249-75-8 methyl lithocholate 
• 1173-32-6 methyl 3-oxo-5β-cholan-24-oate 
• 104874-33-1 methyl 2β,4β-dibromo-3-oxo-5β-cholan-24-oate 
• 52032-50-5 methyl 2β-bromo-3-oxo-5β-cholan-24-oate 
• 99598-20-6 2,4-didromo-3-oxo lithicholic acid methyl ester 

Relevant articles and documents

1β-hydroxylation in 5β-steroids: An efficient synthesis of 1β,3α-dihydroxy-5β-cholan-24-oic acid

An efficient method for the oxyfunctionalization at C-1 in 5β-steroid (A/B-cis) is described as exemplified by conversion of lithocholic acid (3α-hydroxy-5β-cholan-24-oic acid) to 1β,3α-dihydroxy-5β-cholan-24-oic acid. The key reactions used are regioselective functionalization at C-2 in the 5β-steroid nucleus, stereoselective epoxidation of intermediary α,β-conjugated ketone with dimethyldioxirane, and subsequent reductive cleavage of the resulting β-epoxy-ketone with PhSeNa.

Synthesis of the 1 beta-hydroxylated bile acids, unusual bile acids in human biological fluids.

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