892550-43-5

Basic information

• Product Name: 6-chloro-2-(2,6-dibromophenyl)-1H-phenanthro[9,10-d]imidazole
• Synonyms: 6-chloro-2-(2,6-dibromophenyl)-1H-phenanthro[9,10-d]imidazole
• CAS NO: 892550-43-5
• Molecular Weight: 486.593
• Mol File: 892550-43-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-(2,6-dibromophenyl)-1H-phenanthro[9,10-d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(2,6-dibromophenyl)-1H-phenanthro[9,10-d]imidazole(892550-43-5)
• EPA Substance Registry System: 6-chloro-2-(2,6-dibromophenyl)-1H-phenanthro[9,10-d]imidazole(892550-43-5)

Safety Data

• Hazardous Substances Data: 892550-43-5(Hazardous Substances Data)

Upstream product

• 56961-99-0 3-chlorophenanthrene-9,10-dione 
• 67713-23-9 2,6-dibromobenzaldehyde 

Relevant articles and documents

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Phenanthrene imidazole 3 (MF63) has been identified as a novel potent, selective, and orally active mPGES-1 inhibitor. This new series was developed by lead optimization of a hit from an internal HTS campaign. Compound 3 is significantly more potent than the previously reported indole carboxylic acid 1 with an A549 whole cell IC50 of 0.42 μM (50% FBS) and a human whole blood IC50 of 1.3 μM. It exhibited a significant analgesic effect in a guinea pig hyperalgesia model when orally dosed at 30 and 100 mg/kg.

METHODS FOR TREATING OR PREVENTING NEOPLASIAS

The present invention is directed to a method for treating or preventing a neoplasia in a human patient in need of such treatment comprising administering to the patient a compound that inhibits microsomal prostaglandin E synthase-1 in an amount that is effective for treating or preventing the neoplasia.