89267-47-0

Basic information

• Product Name: Furo[3,4-b]pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, ethyl ester
• CAS NO: 89267-47-0
• Molecular Formula: C17H16N2O6
• Molecular Weight: 344.324
• Mol File: 89267-47-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Furo[3,4-b]pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,4-b]pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, ethyl ester(89267-47-0)
• EPA Substance Registry System: Furo[3,4-b]pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-2-methyl-4-(3-nitrophenyl)-5-oxo-, ethyl ester(89267-47-0)

Safety Data

• Hazardous Substances Data: 89267-47-0(Hazardous Substances Data)

Upstream product

• 62760-94-5 diethyl-2-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 141-97-9 ethyl acetoacetate 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 204848-35-1 2-bromomethyl-3,5-dicarboethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine 
• 35594-15-1 ethyl 4-acetoxyacetoacetate 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 99-61-6 3-nitro-benzaldehyde 
• 626-34-6 ethyl aminocrotonate 
• 62760-70-7 diethyl 2-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Downstream Products

• 89288-25-5 ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro<3,4-b>3-pyridinecarboxylate 

Relevant articles and documents

Synthesis of unsymmetrical 1, 4-dihydropyridine derivatives in ionic liquid and inference on the formation mechanism of furopyridines

Aromatic aldehydes, methyl acetoacetate, ethyl acetoacetate, ammonium acetate, ethyl 4-chloroacetoacetate as materials, eight unsymmetrical 1, 4-dihydropyridine derivatives were synthesized in ionic liquid [Bmim]OH in short time with the 60%-90% yield, and the ionic liquid could be utilized for 5 times repeatedly with the no decrease of the yield, four of products [3(a-d)] (see in Table-1) were synthesized through Knoevenagel and Michael addition reaction, and another four Furopyridines [3(e-h)] (see in Table-2) through one-pot synthesis whose formation mechanism being different from that of [3(a-d)] was first inferred.

Synthesis of novel asymmetrical 1,4-dihydropyridine derivatives

Asymmetrical 1,4-dihydropyridine esters 3a and 3i-k were synthesized from the symmetrical precursor 1 through the intermediate 2-bromomethyl derivative 2. Then, compound 3a was subjected to a different transformation for preparation of 1,4-dihydropyridine

Circulation-active hydroxy-tetra-hydropyridinelactones

Hydroxytetrahydropyridinelactones of the formula STR1 in which R represents a phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, quinolyl, isoquinolyl, indolyl, ben