892874-49-6 Usage
Description
7-Chloroquinoline-3-carboxylic acid is an organic compound with the chemical formula C10H6ClNO2. It is a derivative of quinoline-3-carboxylic acid, featuring a chlorine atom at the 7th position and a carboxylic acid group at the 3rd position. 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID is known for its potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
7-Chloroquinoline-3-carboxylic acid is used as a reactant in the preparation of N-(het)arylmethyl)heteroaryl-carboxamides. These compounds serve as plasma kallikrein inhibitors, which are important in the development of drugs targeting various medical conditions, such as inflammation and blood clotting disorders. The inhibition of plasma kallikrein can help regulate the body's inflammatory response and prevent excessive blood clotting, making 7-chloroquinoline-3-carboxylic acid a valuable component in the synthesis of these therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 892874-49-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,2,8,7 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 892874-49:
(8*8)+(7*9)+(6*2)+(5*8)+(4*7)+(3*4)+(2*4)+(1*9)=236
236 % 10 = 6
So 892874-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H6ClNO2/c11-8-2-1-6-3-7(10(13)14)5-12-9(6)4-8/h1-5H,(H,13,14)
892874-49-6Relevant articles and documents
A 3 - amino -7 - chloroquinolin synthetic method (by machine translation)
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Paragraph 0049; 0050, (2018/09/26)
The invention provides a 3 - amino - 7 - chloroquinolin synthetic method. Synthesis method of the invention, in order to 4 - chloro - 1 - methyl - 2 - nitrobenzene as the raw materials, and N, N - dimethyl formamide dimethyl acetal to hydroformylation reaction to produce 4 - chloro - 2 - nitrobenzaldehyde, with 3, 3 - diethyl oxygen radical propionic acid ethyl ester to ring-closure reaction to produce 7 - chloro - 3 - quinoline carboxylic acid ethyl ester, under basic condition to produce 7 - chloro - 3 - quinoline carboxylic acid, with the azido diphenyl phosphate through Curtius rearrangement reaction to 3 - tert-butoxycarbonyl amino - 7 - chloroquinolin, finally through takes off uncle butoxycarbonyl to obtain 3 - amino - 7 chloroquinolin. The invention of 3 - amino - 7 - chloroquinolin synthetic method, the synthetic route is simple, reasonable process, low material cost, simple and easy to obtain, operation and after treatment is convenient, the total yield is high, easy to enlarge, can be large-scale production of 3 - amino - 7 - chloroquinolin. (by machine translation)