893413-42-8

Basic information

• Product Name: PyClocK
• Synonyms: PyClocK;6-Chloro-Benzotriazole-1-yl-oxy-tris-Pyrrolidino-Phosphonium Hexafluorophosphate;(T-4)-[6-Chloro-1-(hydroxy-O)-1H-benzotriazolato]tri-1-pyrrolidinylphosphorus(1+) hexafluorophosphate(1-);PyCOP;(6-Chlorobenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate;(6-Chlorobenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate 97%;PyClock 6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate Novabiochem;(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate
• CAS NO: 893413-42-8
• Molecular Formula: C18H27ClF6N6OP2
• Molecular Weight: 554.8375212
• EINECS: 1592732-453-0
• Mol File: 893413-42-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 118-120℃
• Boiling Point: 449.7°C at 760 mmHg
• Flash Point: 225.8°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 2.79E-08mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• CAS DataBase Reference: PyClocK(CAS DataBase Reference)
• NIST Chemistry Reference: PyClocK(893413-42-8)
• EPA Substance Registry System: PyClocK(893413-42-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 893413-42-8(Hazardous Substances Data)

Usage

Description

PyClocK, also known as (6-Chlorobenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, is a 6-chloro analog of PyBOP. It is a versatile coupling reagent used in various chemical reactions, particularly in the synthesis of peptides and other organic compounds. Its unique structure and properties make it a valuable tool in the field of organic chemistry.

Uses

Used in Peptide Synthesis:
PyClocK is used as a coupling reagent in solution and solid-phase peptide synthesis. It facilitates the formation of peptide bonds between amino acids, enabling the synthesis of various peptide models.
Used in Suppressing Racemization:
PyClocK is used to suppress racemization during the synthesis of various peptide models. This helps to maintain the desired chirality and stereochemistry of the synthesized peptides, which is crucial for their biological activity and potential applications.
Used in Organic Chemistry:
PyClocK is also used in various organic reactions, such as the formation of amide bonds, esterification, and other condensation reactions. Its reactivity and selectivity make it a valuable reagent in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
PyClocK is used in the development of new drugs and drug candidates. Its ability to facilitate the synthesis of complex peptides and other bioactive molecules makes it a valuable tool in the discovery and optimization of new therapeutic agents.
Used in Research and Development:
PyClocK is used in academic and industrial research settings to explore new synthetic routes and develop innovative chemical processes. Its versatility and efficiency make it a popular choice for chemists working on a wide range of projects.
Used in Chemical Synthesis Education:
PyClocK is also used as a teaching tool in chemistry education, helping students understand the principles of peptide synthesis and other organic reactions. Its straightforward use and effectiveness make it an excellent choice for laboratory demonstrations and practical exercises.

InChI:InChI=1/C18H26N2O2S/c1-12(2)15-9-16(13(3)4)18(17(10-15)14(5)6)23(21,22)20-8-7-19-11-20/h7-14H,1-6H3