893741-59-8

Basic information

• Product Name: 3-(5-acetylthiophen-2-yl)benzonitrile
• CAS NO: 893741-59-8
• Molecular Weight: 227.287
• Mol File: 893741-59-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(5-acetylthiophen-2-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-acetylthiophen-2-yl)benzonitrile(893741-59-8)
• EPA Substance Registry System: 3-(5-acetylthiophen-2-yl)benzonitrile(893741-59-8)

Safety Data

• Hazardous Substances Data: 893741-59-8(Hazardous Substances Data)

Upstream product

• 6310-09-4 2-acetyl-5-chlorothiophene 
• 214360-46-0 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 

Relevant articles and documents

Carbon-boron bond cross-coupling reaction catalyzed by -PPh2 containing palladium-indolylphosphine complexes

This study describes the application of indolylphosphine ligands with a diphenylphosphino moiety to the palladium-catalyzed borylation of aryl chlorides. The combination of palladium metal precursor with PPh 2-Andole-phos, which comprises an inexpensive -PPh2 group, provides highly effective catalysts for the borylation of aryl chlorides. A range of functional groups such as -CN, -NO2, -CHO, -COMe, -COOMe, and -CF3 was compatible, and the catalyst loading down to 0.025 mol % of Pd can be achieved. The Pd/PPh2-Andole-phos system is able to catalyze both borylation reaction and Suzuki-Miyaura coupling reaction in a one-pot sequential manner for the direct synthesis of biaryl compounds in excellent yields.