89376-77-2

Basic information

• Product Name: (10xi)-17-ethynyl-10-hydroperoxy-17-hydroxyestra-1,4-dien-3-one
• CAS NO: 89376-77-2
• Molecular Formula: C₂₀H₂₄O₄
• Molecular Weight: 328.4022
• Mol File: 89376-77-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 514.8°C at 760 mmHg
• Flash Point: 183.8°C
• Density: 1.28g/cm³
• Vapor Pressure: 9.48E-13mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: (10xi)-17-ethynyl-10-hydroperoxy-17-hydroxyestra-1,4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (10xi)-17-ethynyl-10-hydroperoxy-17-hydroxyestra-1,4-dien-3-one(89376-77-2)
• EPA Substance Registry System: (10xi)-17-ethynyl-10-hydroperoxy-17-hydroxyestra-1,4-dien-3-one(89376-77-2)

Safety Data

• Hazardous Substances Data: 89376-77-2(Hazardous Substances Data)

Usage

Description

(10xi)-17-ethynyl-10-hydroperoxy-17-hydroxyestra-1,4-dien-3-one is a synthetic hormone compound derived from estradiol, a key hormone in the female reproductive system. It features a rare hydroperoxy group, which endows it with unique properties and potential therapeutic applications. Further research is required to explore its full biological effects and uses.

Uses

Used in Pharmaceutical Industry:
(10xi)-17-ethynyl-10-hydroperoxy-17-hydroxyestra-1,4-dien-3-one is used as a potential therapeutic agent for various hormonal-related conditions due to its potent hormonal activity and unique structural features. Its distinctive properties may offer new avenues for treatment and management of conditions influenced by the female reproductive system.

Upstream product

• 57-63-6 ethinyl estradiol 

Relevant articles and documents

Photosensitized decomposition of contraceptive steroids: A possible explanation for the observed (photo)allergy of the oral contraceptive pill

The photo-sensitized decomposition of the main steroids used in the oral contraceptive pill has been studied. Under the circumstances applied, 1 and 8 decomposed rapidly (t( 1/2 ) = 11.0 ± 0.2 min for 1 and 5.7 ± 0.4 min for 8). The decomposition product of 1 has been identified as 17α-ethynyl-10β-hydroperoxy-17β-hydroxyestra-1,4-dien-3-one (2). The decomposition products of 1 and 8 were previously found in experiments in which the irreversible binding of these steroids to protein was studied. Photosensitized decomposition of the steroids may be the cause of (photo)allergic side-effects of 'the pill'. The photosensitized decomposition of the main steroids used in oral contraceptives was studied. Under the circumstances applied, ethinyl estradiol and norethynodrel decomposed rapidly (t 1/2 = 11.0 + or - 0.2 minutes for ethinyl estradiol and 5.7 + or - 0.4 minutes for norethynodrel). The decomposition product of ethinyl estradiol has been identified as 17 alpha-ethynyl-10 beta-hydroperoxy-17 beta-hydroxyestra-1,4-dien-3-one. The decomposition products of ethinyl estradiol and norethnodrel were previously found in experiments in which the irreversible binding of these steroids to protein was studied. Photosensitized decomposition of the steroids may be the cause of photoallergic side effects of "the pill." author's modified