89379-94-2

Basic information

• Product Name: N-(6-ChloropyriMidin-4-yl)acetaMide
• Synonyms: N-(6-ChloropyriMidin-4-yl)acetaMide
• CAS NO: 89379-94-2
• Molecular Formula: C₆H₆ClN₃O
• Molecular Weight: 171.58434
• Mol File: 89379-94-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(6-ChloropyriMidin-4-yl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-ChloropyriMidin-4-yl)acetaMide(89379-94-2)
• EPA Substance Registry System: N-(6-ChloropyriMidin-4-yl)acetaMide(89379-94-2)

Safety Data

• Hazardous Substances Data: 89379-94-2(Hazardous Substances Data)

Usage

General Description

N-(6-Chloropyrimidin-4-yl)acetamide is a chemical compound with the molecular formula C7H8ClN3O. It is a derivative of pyrimidine and is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceutical compounds. N-(6-ChloropyriMidin-4-yl)acetaMide has a wide range of applications, including as an antiviral agent, an antibacterial agent, and as a potential treatment for various diseases. It is also used in the research and development of new pharmaceutical products. Additionally, it is known for its role as a building block in organic synthesis and medicinal chemistry, making it a valuable compound in the field of drug discovery and development.

Upstream product

• 5305-59-9 4-amino-6-chloropyrimidine 
• 108-24-7 acetic anhydride 
• 60-35-5 acetamide 
• 1193-21-1 4,6-dichloropyrimidine 

Downstream Products

• 849404-99-5 C₂₆H₃₁N₅O₃ 
• 1072710-97-4 6-[[6-(acetylamino)-pyrimidin-4-yl]oxy]-naphthalene-1-carboxylic acid [3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-amide 
• 929113-03-1 C₁₂H₁₈N₄O₃ 
• 849404-96-2 C₂₃H₃₃N₅O₃ 

Relevant articles and documents

Pyrimidine hydrazone derivative and preparation method and application thereof

The invention relates to pyrimidine hydrazone derivatives as shown in a chemical structural formula I or II, pharmaceutically acceptable salts and pharmaceutical compositions thereof, and an application of the pyrimidine hydrazone derivatives and the pharmaceutically acceptable salts and the pharmaceutical compositions in preparation of influenza virus neuraminidase inhibitors, wherein X is selected from: fluorine, chlorine, bromine, hydroxyl, dihydroxy, 2-hydroxy-3-methoxy, 2-hydroxy-4-methoxy, 2-hydroxy-5-C1-C2 alkoxy, 2-hydroxy-6-C1-C2 alkoxy, 3-hydroxy-2-C1-C2 alkoxy, 3-hydroxy-4-C1-C2 alkoxy, 3-hydroxy-5-methyl C1-C2 alkoxy , 3-hydroxy-6-C1-C2 alkoxy, 4-hydroxy-2-C1-C2 alkoxy, 4-hydroxy-3-C1-C2 alkoxy, 4-hydroxy-3, 5-diC1-C2 alkoxy, trihydroxy or 4-hydroxy-3,5-dimethyl; and Y is selected from: fluorine, chlorine, bromine, acetamido, hydroxyl or methoxy.

Novel pyrimidine derivative kinase inhibitor

The invention relates to a kinase inhibitor comprising a compound of formula I or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The invention also relates toa pharmaceutical composition comprising the kinase inhibitor, use of the compound and composition to inhibit wild type FLT3, mutant type FLT3-ITD, PDGFR[alpha] and/or PDGFR[beta] kinase activity in cells or subjects, and uses and methods for preventing or treating kinase-related disorders in the subjects.

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

This invention provides compounds of formula (I): wherein R1, R1b, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.