89393-00-0Relevant articles and documents
γ-halo-enones: A method for their synthesis from arylacyl halides and their application to the preparation of five-membered ring heterocycles
Lin, Mei-Huey,Huang, Yen-Chih,Kuo, Chung-Kai,Tsai, Chang-Hsien,Li, Yi-Syuan,Hu, Ting-Chia,Chuang, Tsung-Hsun
, p. 2751 - 2757 (2014/04/17)
A simple method has been developed for synthesis of γ-halo-enones. The approach employs a sequence involving initial indium-mediated allenylation reactions of phenacyl halides with propargyl bromide. This process is followed by acid-promoted rearrangement reactions of the formed homoallenic halohydrins. The new method can be incorporated into routes for the efficient synthesis of various five-membered heterocyclic compounds.