894086-00-1 Usage
Description
5-(DI-TERT-BUTYLPHOSPHINO)-1', 3', 5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE is a non-proprietary ligand that plays a crucial role in palladium-catalyzed amination reactions involving aryl halides, including aryl chlorides. Its unique structure and properties make it an effective choice for enhancing the efficiency and selectivity of these chemical processes.
Uses
Used in Pharmaceutical Industry:
5-(DI-TERT-BUTYLPHOSPHINO)-1', 3', 5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE is used as a non-proprietary ligand for palladium-catalyzed amination of aryl halides, including aryl chlorides, to facilitate the synthesis of various pharmaceutical compounds. Its application in this industry is crucial for the development of new drugs and the improvement of existing ones.
Used in Chemical Research:
In the field of chemical research, 5-(DI-TERT-BUTYLPHOSPHINO)-1', 3', 5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE is used as a ligand to improve the efficiency and selectivity of palladium-catalyzed amination reactions. This allows researchers to explore new chemical pathways and develop innovative synthetic methods.
Used in Material Science:
5-(DI-TERT-BUTYLPHOSPHINO)-1', 3', 5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE is employed as a ligand in palladium-catalyzed amination reactions to synthesize novel materials with unique properties. Its use in material science contributes to the development of advanced materials for various applications, such as electronics, energy storage, and sensors.
Optimized for Palladium Source Pd2(dba)3:
The performance of 5-(DI-TERT-BUTYLPHOSPHINO)-1', 3', 5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE as a ligand is optimized when used in conjunction with the palladium source Pd2(dba)3. This combination ensures the highest efficiency and selectivity in palladium-catalyzed amination reactions, making it an ideal choice for various applications across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 894086-00-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,4,0,8 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 894086-00:
(8*8)+(7*9)+(6*4)+(5*0)+(4*8)+(3*6)+(2*0)+(1*0)=201
201 % 10 = 1
So 894086-00-1 is a valid CAS Registry Number.
894086-00-1Relevant articles and documents
Streamlined synthesis of the bippyphos family of ligands and cross-coupling applications
Withbroe, Gregory J.,Singer, Robert A.,Sieser, Janice E.
, p. 480 - 489 (2013/01/03)
We describe the efficient preparation of Bippyphos, 1. The key precursor to Bippyphos, 5, was prepared via a one-pot bromination of diketone 2 followed by alkylation with pyrazole and condensation with phenylhydrazine. Lithiation of 5 and trapping with ditert-butylchlorophosphine afforded Bippyphos, 1. Using this approach we have prepared several derivatives of Bippyphos to probe the structure and activity relationships of this family of phosphine ligands. We also demonstrate the utility of these ligands in Pdcatalyzed amination reactions and other cross-coupling reactions.
