89424-84-0

Basic information

• Product Name: (1,3-dihydroisobenzofuran-5-yl)methanol
• Synonyms: (1,3-dihydroisobenzofuran-5-yl)methanol;1,3-Dihydro-2-Benzofuran-5-Ylmethanol;5-Isobenzofuranmethanol, 1,3-dihydro-;1,3-Dihydro-2-Benzofuran-5-Ylmethanol(WX640337)
• CAS NO: 89424-84-0
• Molecular Formula: C9H10O2
• Molecular Weight: 150.18
• Mol File: 89424-84-0.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1,3-dihydroisobenzofuran-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1,3-dihydroisobenzofuran-5-yl)methanol(89424-84-0)
• EPA Substance Registry System: (1,3-dihydroisobenzofuran-5-yl)methanol(89424-84-0)

Safety Data

• Hazardous Substances Data: 89424-84-0(Hazardous Substances Data)

Usage

General Description

(1,3-dihydroisobenzofuran-5-yl)methanol, also known as 5-Methoxy-1,3-dihydroisobenzofuran, is a chemical compound with the molecular formula C9H10O2. It is a white solid with a sweet, floral odor, and is commonly used in the synthesis of pharmaceuticals and other organic compounds. (1,3-dihydroisobenzofuran-5-yl)methanol has been studied for its potential biological activities, including its antifungal and antibacterial properties. It can also act as an intermediate in the production of various fragrance and flavor compounds. However, due to its potential toxicity and environmental impact, the handling and use of (1,3-dihydroisobenzofuran-5-yl)methanol should be carefully regulated. Overall, this chemical compound has various applications in the pharmaceutical and chemical industries, and its potential biological activities make it an area of interest for further research.

Upstream product

• 6921-27-3 dipropargyl ether 
• 107-19-7 propargyl alcohol 
• 89424-83-9 1,3-dihydroisobenzofuran-5-carbaldehyde 
• 22184-23-2 2,5-dimethylbenzyl acetate 
• 1310458-49-1 2,5-bis(bromomethyl)benzyl acetate 
• 53957-33-8 2,5-dimethylbenzyl alcohol 
• 188111-48-0 5-(bromomethyl)-1,3-dihydroisobenzofuran 

Downstream Products

• 188111-48-0 5-(bromomethyl)-1,3-dihydroisobenzofuran 
• 89424-83-9 1,3-dihydroisobenzofuran-5-carbaldehyde 
• 1187196-40-2 5-(3,5-dichlorophenyl)-3-(1,3-dihydro-2-benzofuran-5-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole 

Relevant articles and documents

Rhodium-NHC hybrid silica materials as recyclable catalysts for [2+2+2] cycloaddition reactions of alkynes

Bis-silylated dihydroimidazolium salt 1 and monosilylated imidazolium salt 2 are transformed to (NHC)RhCl(COD) complexes 3 and 4, allowing the preparation of hybrid silica materials either by sol-gel or grafting processes. Full characterization of the materials by means of solid state NMR, N2-sorption measurements, thermogravimetric analysis (TGA) and elemental analysis was followed by evaluation of catalytic activity in the [2+2+2] cycloaddition of alkynes. Excellent yields of the cycloadducts are obtained for up to six consecutive cycles with the grafted material, using simple filtration to recover the catalyst. Both conventional and microwave heating prove effective for the process described.

Iridium(III)-catalyzed approach for the synthesis of fused arenes: Access to isoindolines, indanes, and dihydroisobenzofurans

A facile and efficient method for the synthesis of isoindoline, indane, and dihydroisobenzofuran derivatives has been developed through the application of a halogen-bridged iridium(III) complex to the [2+2+2] cycloaddition of α,ω-diynes with alkynes. The

Ruthenium carbene mediated [2+2+2] cyclotrimerizations

Second-generation Grubbs catalyst and Hoveyda-Grubbs catalyst are able to catalyze both crossed [2+2+2] cyclotrimerization of diynes with alkynes and di- or trimerizations of diynes. Selection of the reaction conditions allows us to favor one particular p