89466-36-4

Basic information

• Product Name: 3-Chloro-6-methoxy-4-methylpyridazine
• Synonyms: 3-Chloro-6-methoxy-4-methylpyridazine
• CAS NO: 89466-36-4
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 158.58558
• Mol File: 89466-36-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 66 °C
• Boiling Point: 303.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.237±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.65±0.10(Predicted)
• CAS DataBase Reference: 3-Chloro-6-methoxy-4-methylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-6-methoxy-4-methylpyridazine(89466-36-4)
• EPA Substance Registry System: 3-Chloro-6-methoxy-4-methylpyridazine(89466-36-4)

Safety Data

• Hazardous Substances Data: 89466-36-4(Hazardous Substances Data)

Upstream product

• 19064-64-3 3,6-dichloro-4-methylpyridazine 
• 124-41-4 sodium methylate 
• 1722-10-7 3-chloro-6-methoxypyridazine 
• 74-88-4 methyl iodide 

Downstream Products

• 1703-07-7 6-chloro-5-methyl-2H-pyridazin-3-one 
• 54709-94-3 5-methylpyridazin-3(2H)-one 
• 868993-07-1 2-(6-chloro-3-methoxy-5-methylpyridazin-4-yl)-N,N-diethyl-4-fluorobenzamide 

Relevant articles and documents

Diazines VII. A new synthetic route to the pyridazine antidepressant, minaprine using directed ortho metalation and Suzuki cross coupling reactions

A new synthetic route has been developed for minaprine.The synthesis is based upon two reactions recently studied on pyridazine: metalation and cross coupling with transition metals.Some different routes have been tested starting from 3,6-dichloropyridazine.The best results were obtained by coupling phenylboronic acid with 3-chloro-6-methoxypyridazine then by metalating 3-methoxy-6-phenylpyridazine and reacting the lithio derivatives with methyl iodide. 3-Methoxy-4-methyl-6-phenylpyridazine was obtained.After hydrolysis of the ether moiety, chlorination and substitution by the amine, minaprine was obtained with an overall yield of 36percent.Keywords - pyridazine / metalation / cross-coupling