89466-38-6

Basic information

• Product Name: 6-Chloro-3-methoxy-4-methylpyridazine
• Synonyms: 6-Chloro-3-methoxy-4-methylpyridazine
• CAS NO: 89466-38-6
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 158.58558
• Mol File: 89466-38-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-Chloro-3-methoxy-4-methylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-3-methoxy-4-methylpyridazine(89466-38-6)
• EPA Substance Registry System: 6-Chloro-3-methoxy-4-methylpyridazine(89466-38-6)

Safety Data

• Hazardous Substances Data: 89466-38-6(Hazardous Substances Data)

Usage

General Description

6-Chloro-3-methoxy-4-methylpyridazine is a chemical compound with the molecular formula C7H8ClN3O. It is a derivative of pyridazine, a six-membered aromatic heterocycle with two nitrogen atoms at positions 1 and 2. The compound is characterized by the presence of a chloro group at position 6, a methoxy group at position 3, and a methyl group at position 4 of the pyridazine ring. It is used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. 6-Chloro-3-methoxy-4-methylpyridazine may also have potential applications in agricultural chemicals, dyes, and organic synthesis.

Upstream product

• 19064-64-3 3,6-dichloro-4-methylpyridazine 
• 124-41-4 sodium methylate 
• 1722-10-7 3-chloro-6-methoxypyridazine 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 66530-55-0 6-chloro-3-hydrazino-4-methylpyridazine 

Downstream Products

• 1834-27-1 6-chloro-4-methyl-2H-pyridazin-3-one 

Relevant articles and documents

2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES

Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R1, R2, R3, Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.

Diazines VII. A new synthetic route to the pyridazine antidepressant, minaprine using directed ortho metalation and Suzuki cross coupling reactions

A new synthetic route has been developed for minaprine.The synthesis is based upon two reactions recently studied on pyridazine: metalation and cross coupling with transition metals.Some different routes have been tested starting from 3,6-dichloropyridazine.The best results were obtained by coupling phenylboronic acid with 3-chloro-6-methoxypyridazine then by metalating 3-methoxy-6-phenylpyridazine and reacting the lithio derivatives with methyl iodide. 3-Methoxy-4-methyl-6-phenylpyridazine was obtained.After hydrolysis of the ether moiety, chlorination and substitution by the amine, minaprine was obtained with an overall yield of 36percent.Keywords - pyridazine / metalation / cross-coupling