89469-44-3

Basic information

• Product Name: 2-METHOXY-4-[(METHYLSULFONYL)AMINO]BENZOIC ACID
• Synonyms: 2-METHOXY-4-[(METHYLSULFONYL)AMINO]BENZOIC ACID
• CAS NO: 89469-44-3
• Molecular Formula: C₉H₁₁NO₅S
• Molecular Weight: 245.25
• Mol File: 89469-44-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHOXY-4-[(METHYLSULFONYL)AMINO]BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-4-[(METHYLSULFONYL)AMINO]BENZOIC ACID(89469-44-3)
• EPA Substance Registry System: 2-METHOXY-4-[(METHYLSULFONYL)AMINO]BENZOIC ACID(89469-44-3)

Safety Data

• Hazardous Substances Data: 89469-44-3(Hazardous Substances Data)

Upstream product

• 620612-15-9 4-methanesulfonylamino-2-methoxybenzoic acid methyl ester 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 89454-49-9 2-(2'-methoxy-4'-methanesulfonylamino-phenyl)-benzimidazole 
• 89454-53-5 5-Chloro-2-(2'-methoxy-4'-methanesulfonylamino-phenyl)-benzimidazole 
• 100079-13-8 2-(4'-methanesulfonylamino-2'-methoxy-phenyl)-imidazo[4,5-c]pyridine 
• 89454-52-4 5-Methoxy-2-(2'-methoxy-4'-methanesulfonylamino-phenyl)-benzimidazole 
• 89454-37-5 8-(2'-methoxy-4'-methanesulfonylamino-phenyl)-purine 

Relevant articles and documents

Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity

Highly potent and selective 4-amidofuran-3-one inhibitors of cathepsin S are described. The synthesis and structure-activity relationship of a series of inhibitors with a sulfonamide moiety in the P3 position is presented. Several members of the series show sub-nanomolar inhibition of the target enzyme as well as an excellent selectivity profile and good cellular potency. Molecular modeling of the most interesting inhibitors describes interactions in the extended S3 pocket and explains the observed selectivity towards cathepsin K.