89478-03-5

Basic information

• Product Name: 1,4-Naphthalenedione, 2-[(4-methylphenyl)thio]-
• CAS NO: 89478-03-5
• Molecular Formula: C17H12O2S
• Molecular Weight: 280.347
• Mol File: 89478-03-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,4-Naphthalenedione, 2-[(4-methylphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 2-[(4-methylphenyl)thio]-(89478-03-5)
• EPA Substance Registry System: 1,4-Naphthalenedione, 2-[(4-methylphenyl)thio]-(89478-03-5)

Safety Data

• Hazardous Substances Data: 89478-03-5(Hazardous Substances Data)

Upstream product

• 39549-10-5 1-[(4-methylphenyl)sulfanyl]pyrrolidine-2,5-dione 
• 130-15-4 [1,4]naphthoquinone 
• 103-19-5 di(p-tolyl) disulfide 
• 26473-08-5 [²H₆]-1,4-naphthoquinone 
• 10075-62-4 1,4-dimethoxynaphthalene 
• 106-45-6 para-thiocresol 
• 145146-93-6 1,4-Dimethoxy-2-<(4-methylphenyl)thio>naphthalene 

Downstream Products

• 1025772-46-6 C₁₇H₁₄O₂S 
• 1099739-80-6 2,3-di-(4-methylphenyl)sulphanyl-1,4-naphthalenediol 
• 1146805-85-7 2-(4-methylphenyl)-3-(4-bromophenyl)sulphanyl-1,4-naphthalenediol 
• 1146805-84-6 2-(4-methylphenyl)-3-(4-methoxyphenyl)sulphanyl-1,4-naphthalenediol 
• 114740-45-3 bis-2-(4-phenyl)-3-(4-bromophenyl)sulphanyl-1,4-naphthalenedione 
• 89478-07-9 2-bromo-3-p-tolylsulfanyl-[1,4]naphthoquinone 

Relevant articles and documents

Synthetic method for quinone aryl thioether compounds

The invention relates to a synthetic method for quinone aryl thioether compounds represented by a formula (III). The method comprises the following steps: in an organic solvent, in the presence of a catalyst, an oxidizing agent, an organic ligand and an accelerant, performing a reaction on a compound represented by a formula (I) and a compound represented by a formula (II) for 6-10 hours at 50-70 DEG C; after reaction, performing post-treatment to obtain the compound represented by a formula (III) as shown in the description, wherein R is selected from H, C1-C6 alkyl, C1-C6 alkoxyl, halogen or nitryl. Through comprehensive screening and synergistic effect of the catalyst, the oxidizing agent, the organic ligand, the accelerant and the organic solvent, the method can obtain the targeted product at a high yield. The invention provides a brand-new synthetic method for the compounds and has good application values and industrial production potentials.

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

A series of analogs of 2-tosylnaphthalene-1,4-diol were prepared and were found to be potent 10-20 nM reversible inhibitors of the Escherichia coli FabH enzyme. The inhibitors were also effective but to a lesser degree (30 nM-5 μM), against the Mycobacter

Asymmetric Diels-Alder Reactions of (S)-2-(p-Tolylsulfinyl)-1,4-naphthoquinones

The asymmetric Diels-Alder reactions of (S)-2-(p-tolylsulfinyl)-1,4-naphthoquinones 1a-c with cyclic dienes have been explored.The high ? facial diastereoselectivity observed can be reversed in the presence of ZnBr2.Evidence is presented to show that the regiochemical outcome of these reactions is controlled only by the sulfinyl group.The in situ cycloaddition/pyrolytic sulfoxide elimination starting from chiral 1a-c offers a convenient new route for the construction of enantiomerically pure 1,4-dihydro-9,10-anthraquinones (+)-10 and (+)-12a-c.