894787-30-5 Usage
Biological Activity
st 2825 is a specific inhibitor of myd88 dimerization [1].st 2825 is a synthetic compound which mimics the structure of the heptapeptide in the bb-loop of the myd88-tir domain and interferes the homodimerization of myd88. st 2825 was proved to specifically inhibit the homodimerization of myd88 tir domains without affecting the homodimerization of death domains. in hek293t cells transfected with flag-myd88 and myc-myd88, st 2825 inhibited the interaction of the two myd88 by 80% at the concentration of 10 μm. this inhibition resulted in the subsequent interference of the irak1 and irak4 recruitment. besides that, administration of st 2825 significantly inhibited the il-6 production stimulated by il-1β at doses of 100 and 200 mg/kg in mice. furthermore, 8 μm st 2825 completely blocked the tlr9-induced b cell proliferation. st2825 also suppressed the generation of plasma cells induced by cpg dose-dependently [1].
references
[1] loiarro m, capolunghi f, fantò n, et al. pivotal advance: inhibition of myd88 dimerization and recruitment of irak1 and irak4 by a novel peptidomimetic compound. journal of leukocyte biology, 2007, 82(4): 801-810.
Check Digit Verification of cas no
The CAS Registry Mumber 894787-30-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,4,7,8 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 894787-30:
(8*8)+(7*9)+(6*4)+(5*7)+(4*8)+(3*7)+(2*3)+(1*0)=245
245 % 10 = 5
So 894787-30-5 is a valid CAS Registry Number.
894787-30-5Relevant articles and documents
Design, synthesis, and in vitro activity of peptidomimetic inhibitors of myeloid differentiation factor 88
Fantò, Nicola,Gallo, Grazia,Ciacci, Andrea,Semproni, Mauro,Vignola, Davide,Quaglia, Marco,Bombardi, Valentina,Mastroianni, Domenico,Zibella, M. Pia,Basile, Giancarlo,Sassano, Marica,Ruggiero, Vito,De Santis, Rita,Carminati, Paolo
, p. 1189 - 1202 (2008/09/20)
We describe the design and synthesis of a peptidomimetic library derived from the heptapeptide AC-RDVLPGT-NH2, belonging to the Toll/IL-1 receptor (TIR) domain of the adaptor protein MyD88 and effective in inhibiting its homodimerization. The a
