895-32-9

Basic information

• Product Name: Cycloheptanone, 2,7-bis(2-furanylmethylene)-
• CAS NO: 895-32-9
• Molecular Formula: C17H16O3
• Molecular Weight: 268.312
• Mol File: 895-32-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 114 °C (ethanol)
• CAS DataBase Reference: Cycloheptanone, 2,7-bis(2-furanylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cycloheptanone, 2,7-bis(2-furanylmethylene)-(895-32-9)
• EPA Substance Registry System: Cycloheptanone, 2,7-bis(2-furanylmethylene)-(895-32-9)

Safety Data

• Hazardous Substances Data: 895-32-9(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 502-42-1 cycloheptanone 

Relevant articles and documents

Synthesis, molecular modeling and bio-evaluation of cycloalkyl fused 2-aminopyrimidines as antitubercular and antidiabetic agents

An economical and efficient one step synthesis of a series of 8-(arylidene)-4-(aryl)-5,6,7,8-tetrahydro-quinazolin-2-ylamines and 9-(arylidene)-4-(aryl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamines by the reaction of bis-benzylidene cycloalkanones and guanidine hydrochloride in presence of NaH has been developed. All the synthesized compounds were evaluated against Mycobacterium tuberculosis H37Rv strain and the α-glucosidase and glycogen phosphorylase enzymes. Few of the compounds have shown interesting in vitro activity with MIC up to 3.12 μg/mL against M. tuberculosis and very good inhibition of α-glucosidase and glycogen phosphorylase enzymes. The most potent non toxic compound 40 exhibited about 58% ex vivo activity at MIC of 3.12 μg/mL. The present study opens a new gate to synthesize antitubercular agents for diabetic TB patients. In silico docking studies indicate that mycobacterial dihydrofolate reductase is the possible target of these compounds.

Convenient synthesis of α,α1-bis (substituted furfurylidene) cycloalkanones and chalcones under microwave irradiation

Condensation of furfural with cycloalkanones and substituted acetophenones catalyzed by solid NaOH results in α,α1-bis (substituted furfurylidene) cycloalkanones and chalcones in high yield under microwave irradiation for a duration of 2 minute