895131-39-2Relevant articles and documents
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists
Besidski, Yevgeni,Brown, William,Bylund, Johan,Dabrowski, Michael,Dautrey, Sophie,Harter, Magali,Horoszok, Lucy,Hu, Yin,Johnson, Dean,Johnstone, Shawn,Jones, Paul,Leclerc, Sandrine,Kolmodin, Karin,Kers, Inger,Labarre, Maryse,Labrecque, Denis,Laird, Jennifer,Lundstroem, Therese,Martino, John,Maudet, Mickael,Munro, Alexander,Nyloef, Martin,Penwell, Andrea,Rotticci, Didier,Slaitas, Andis,Sundgren-Andersson, Anna,Svensson, Mats,Terp, Gitte,Villanueva, Huascar,Walpole, Christopher,Zemribo, Ronald,Griffin, Andrew M.
, p. 6205 - 6211 (2012/10/29)
Benzothiazole amides were identified as TRPV1 antagonists from high throughput screening using recombinant human TRPV1 receptor and structure-activity relationships were explored to pinpoint key pharmacophore interactions. By increasing aqueous solubility