89524-99-2

Basic information

• Product Name: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
• Synonyms: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE;methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate;Acetic acid, (acetylaMino)(diMethoxyphosphinyl)-, Methyl ester;Methyl alpha-(acetylamino)-alpha-(dimethoxyphosphoryl)acetate;Acetic acid,2-(acetylaMino)-2-(diMethoxyphosphinyl)-, Methyl ester;Ac-Gly(PO(OMe)2-OMe
• CAS NO: 89524-99-2
• Molecular Formula: C₇H₁₄NO₆P
• Molecular Weight: 239.16
• Mol File: 89524-99-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 88.0-88.5℃
• Boiling Point: 385.305°C at 760 mmHg
• Flash Point: 186.826°C
• Appearance: /
• Density: 1.254g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.439
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.20±0.46(Predicted)
• CAS DataBase Reference: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE(89524-99-2)
• EPA Substance Registry System: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE(89524-99-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 89524-99-2(Hazardous Substances Data)

Usage

Description

METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE, also known as Trimethyl α-(Acetamido)phosphonoacetate, is a chemical compound that serves as a histone deacetylase (HDAC) inhibitor. It has the potential to treat a variety of diseases, including cell proliferative diseases, autoimmune diseases, inflammation, neurodegenerative diseases, and viral diseases.

Uses

Used in Pharmaceutical Industry:
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE is used as an HDAC inhibitor for treating cell proliferative diseases, such as cancer, by regulating gene expression and cell cycle progression.
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE is used as an HDAC inhibitor for managing autoimmune diseases by modulating the immune system and reducing inflammation.
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE is used as an HDAC inhibitor for treating inflammatory conditions by reducing inflammation and promoting tissue repair.
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE is used as an HDAC inhibitor for addressing neurodegenerative diseases, such as Alzheimer's and Parkinson's, by protecting neurons and reducing oxidative stress.
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE is used as an HDAC inhibitor for combating viral diseases by modulating the host's immune response and inhibiting viral replication.

InChI:InChI=1/C7H14NO6P/c1-5(9)8-6(7(10)12-2)15(11,13-3)14-4/h6H,1-4H3,(H,8,9)

Upstream product

• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 142055-99-0 (E)-2-Acetylamino-but-2-enedioic acid 4-tert-butyl ester 1-methyl ester 
• 142056-01-7 (Z)-2-Acetylamino-but-2-enedioic acid 4-tert-butyl ester 1-methyl ester 
• 57294-56-1 (Z)-methyl 2-acetamido-3-methoxyacrylate 
• 253332-82-0 thieno[3,2-c]pyridine-6-carboxylic acid methyl ester 
• 253332-81-9 thieno[2,3-c]pyridin-5-carboxylic acid methyl ester 
• 1593978-40-5 (Z)-methyl α-acetamido-3-(3,4,5-trimethylphenyl)acrylate 
• 141540-70-7 Methyl 4-phenoxy-2-N-acetylaminobut-2(E)-enoate 
• 141540-70-7 Methyl 4-phenoxy-2-N-acetylaminobut-2(Z)-enoate 
• 141540-63-8 Methyl 4-(4-chlorophenoxy)-2-N-acetylaminobut-2(E)-enoate 
• 141540-72-9 Methyl 4-(4-chlorophenoxy)-2-N-acetylaminobut-2(Z)-enoate 
• 925932-13-4 C₁₃H₁₂F₃NO₃ 
• 17355-24-7 (S)-N-acetyl-3-(4-methoxyphenyl)alanine methyl ester 
• 52386-78-4 N-acetyl dehydrophenylalanine methyl ester 
• 3618-96-0 (S)-N-acetylphenylalanine 

Relevant articles and documents

A new convenient synthesis of N-acyl-2-(dimethoxyphosphoryl)glycinates

Easily accessible N-acyl-2-triphenylphosphonioglycinate tetrafluoroborates react smoothly with trimethylphosphite in the presence of methyltriphenylphosphonium iodide to give N-acyl-2-(dimethoxyphosphoryl)glycinates in good or very good yields. The dimeth