89536-99-2

Basic information

• Product Name: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucyl]-N-methyl-, phenylmethyl ester
• CAS NO: 89536-99-2
• Molecular Formula: C25H40N2O5
• Molecular Weight: 448.603
• Mol File: 89536-99-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucyl]-N-methyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucyl]-N-methyl-, phenylmethyl ester(89536-99-2)
• EPA Substance Registry System: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucyl]-N-methyl-, phenylmethyl ester(89536-99-2)

Safety Data

• Hazardous Substances Data: 89536-99-2(Hazardous Substances Data)

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 53363-89-6 N-t-butoxycarbonyl-N-methyl-L-leucine 
• 89536-89-0 benzyl (2S)-3-methyl-2-(methylamino)butanoate hydrochloride 
• 16652-76-9 L-valine benzyl ester p-toluenesulfonate salt 
• 81135-38-8 benzyl (2S)-3-methyl-2-(methylamino)butanoate 
• 1356155-99-1 Boc-MeLeu-SH 
• 799779-66-1 (S)-2-Isocyano-3-methyl-butyric acid benzyl ester 
• 109745-93-9 N-Benzyliden-(S)-valin-benzylester 
• 100-52-7 benzaldehyde 
• 45170-31-8 Boc-N-Me-Val-OH 
• 109745-82-6 (S)-2-[(3-Cyano-4,6-dimethyl-pyridin-2-ylsulfanyl)-methyl-amino]-3-methyl-butyric acid benzyl ester 

Downstream Products

• 89537-08-6 Boc-MeLeu-MeLeu-MeVal-OBzl 

Relevant articles and documents

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride (1) as coupling reagent for N-alkyl amino acids

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Expanding the limits of isonitrile-mediated amidations: On the remarkable stereosubtleties of macrolactam formation from synthetic seco -cyclosporins

The scope of isonitrile-mediated amide bond-forming reactions is further explored in this second-generation synthetic approach to cyclosporine (cyclosporin A). Both type I and type II amidations are utilized in this effort, allowing access to epimeric cyclosporins A and H from a single precursor by variation of the coupling reagents. This work lends deeper insight into the relative acylating ability of the formimidate carboxylate mixed anhydride (FCMA) intermediate, while shedding light on the far-reaching impact of remote stereochemical changes on the effective preorganization of seco-cyclosporins.

Synthesis of cyclosporine. Part II. Synthesis of Boc-D-Ala-MeLeu-MeLeu-MeVal-OH, a part of the peptide sequence of cyclosporine, by different strategic ways and synthesis of its isomers Boc-D-Ala-MeLeu-D-MeLeu-MeVal-OH, Boc-D-Ala-Meleu-D-MeLeu-D-MeVal-OH,

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