89562-34-5

Basic information

• Product Name: 5,10-dioxo-N¹,N⁶-diphenyl-5,10-dihydrodiimidazo[1,5-a:1',5'-d]pyrazine-1,6-dicarboxamide
• Synonyms: 5,10-dioxo-N¹,N⁶-diphenyl-5,10-dihydrodiimidazo[1,5-a:1',5'-d]pyrazine-1,6-dicarboxamide
• CAS NO: 89562-34-5
• Molecular Weight: 426.391
• Mol File: 89562-34-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5,10-dioxo-N¹,N⁶-diphenyl-5,10-dihydrodiimidazo[1,5-a:1',5'-d]pyrazine-1,6-dicarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5,10-dioxo-N¹,N⁶-diphenyl-5,10-dihydrodiimidazo[1,5-a:1',5'-d]pyrazine-1,6-dicarboxamide(89562-34-5)
• EPA Substance Registry System: 5,10-dioxo-N¹,N⁶-diphenyl-5,10-dihydrodiimidazo[1,5-a:1',5'-d]pyrazine-1,6-dicarboxamide(89562-34-5)

Safety Data

• Hazardous Substances Data: 89562-34-5(Hazardous Substances Data)

Upstream product

• 59157-06-1 4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride 
• 62-53-3 aniline 
• 570-22-9 4,5-imidazoledicarboxylic acid 

Downstream Products

• 124928-16-1 5-[1-(5-Nitro-furan-2-yl)-meth-(E)-ylidene-hydrazinocarbonyl]-1H-imidazole-4-carboxylic acid phenylamide 
• 89562-40-3 5-Hydrazinocarbonyl-1H-imidazole-4-carboxylic acid phenylamide 

Relevant articles and documents

Synthesis and evaluation of imidazole-4,5-and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus

The results of a high-throughput screening assay using the dengue virus-2 replicon showed that the imidazole 4,5-dicarboxamide (I45DC) derivative (15a) has a high dengue virus inhibitory activity. Based on 15a as a lead compound, a novel class of both disubstituted I45DCs and the resembling pyrazine 2,3-dicarboxamides (P23DCs) were synthesized. Here, we report on their in vitro inhibitory activity against dengue virus (DENV) and yellow fever virus (YFV). Some of these first generation compounds have shown activity against both viruses in the micromolar range. Within this series, compound 15b was observed to display the highest antiviral potency against YFV with an EC50 Combining double low line 1.85 μM. In addition, compounds 20a and 20b both potently inhibited replication of DENV (EC50 Combining double low line 0.93 μM) in Vero cells.

Synthesis and antimicrobial activity of 5-nitrofurfural heteryl hydrazones

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